50세 이상 한국인에서의 무릎 골관절염과 대사증후군의 연관성 = Association of Knee Osteoarthritis with Metabolic Syndrome in Koreans Aged 50-Years or Older

다국어 초록 (Multilingual Abstract)

Background: Recent studies have reported the association of knee osteoarthritis (KOA) with metabolic risk factors. The objective of this study was to evaluate the association between KOA and metabolic syndrome (MetS).
Methods: The study subjects were 966 Korean adults aged ≥50 years who participated in a free-of-charge health examination provided to residents of a non-urban area. We ascertained KOA and MetS on the basis of the clinical diagnostic criteria of the American Rheumatism Association and the modified National Cholesterol Education Program’s Adult Treatment Panel III, respectively. The association between KOA and MetS was evaluated using a multiple logistic regression analysis after adjusting for covariates.
Results: The overall prevalence rates of KOA and MetS were 34.9% and 48.7%, respectively, with higher prevalence rates in the women than in the men (P<0.001). The risk of MetS was significantly higher in the subjects with KOA than in those without KOA (odds ratio [OR], 1.35; 95% confidence interval [CI], 1.03–1.77). Among the components of MetS, only abdominal obesity showed a significant association with KOA (OR, 1.48; 95% CI, 1.12–1.95). When the analyses were repeated to determine sex-specific relationships, the associations of KOA with MetS (P=0.069) and abdominal obesity (P=0.022) were evident in the women, but not in the men.
Conclusion: The findings of this study suggest that women with KOA must be evaluated and managed for MetS, with special attention to abdominal obesity.

국문 초록 (Abstract)

연구배경:최근무릎골관절염과대사적위험인자들사이의연관성에 대해 보고되었고, 본 연구는 무릎 골관절염과 대사증후군 간의연관성을 평가하기 위해 수행되었다.
방법:연구 대상자는 한국의 비도시지역 거주민을 대상으로 수행된무료건강검진에참여한만 50세이상의성인 966명이었다. 무릎골관절염은 American Rheumatism Association에서제안한환자자가보고에 의한 임상적 진단기준에 따라 판단하였고, 대사증후군은 modified National Cholesterol Education Program’s Adult Treatment Panel III기준에 따라 판정하였다. 무릎 골관절염과 대사증후군 간의 연관성을평가하기위해다변량로지스틱 회귀분석을시행하였다.
결과: 전체 연구 대상자의 무릎 골관절염과 대사증후군의 유병률은 각각 34.9%, 48.7% 였고, 여성에서 남성에 비해 두 질환의 유병률이 모두 유의하게 높았다(P<0.001). 무릎 골관절염이 있는 군에서 없는 군에 비해 대사 증후군의 위험도가 높았다(교차비, 1.35; 95% 신뢰구간, 1.03–1.77). 대사증후군의 구성 요인 중 복부비만 만이 무릎 골관절염과 유의한 연관성을 보였다(교차비, 1.48; 95% 신뢰구간, 1.12–1.95). 성별 분석 결과, 여성에서만 무릎 골관절염과 대사증후군 간에경계적으로 유의한(borderline significant) 연관성이 관찰되었다(교차비, 1.36; 95% 신뢰구간, 0.98–1.89).
결론: 본 연구 결과는 무릎 골관절염이 있는 여성 환자에서 특히 복부비만에 중점을 둔 대사증후군에 대한 평가 및 관리가 필요함을시사한다.

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