The challenging nickel‐catalyzed mono‐α‐arylation of acetone with aryl chlorides, pivalates, and carbamates has been achieved for the first time. A nickel/Josiphos‐based catalytic system is shown to feature unique catalytic behavior, allowing...
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https://www.riss.kr/link?id=O112205011
2020년
-
0044-8249
1521-3757
학술저널
19110-19115 [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
The challenging nickel‐catalyzed mono‐α‐arylation of acetone with aryl chlorides, pivalates, and carbamates has been achieved for the first time. A nickel/Josiphos‐based catalytic system is shown to feature unique catalytic behavior, allowing...
The challenging nickel‐catalyzed mono‐α‐arylation of acetone with aryl chlorides, pivalates, and carbamates has been achieved for the first time. A nickel/Josiphos‐based catalytic system is shown to feature unique catalytic behavior, allowing the highly selective formation of the desired mono‐α‐arylated acetone. The developed methodology was applied to a variety of (hetero)aryl chlorides including biologically relevant derivatives. The methodology has been extended to the unprecedented coupling of acetone with phenol derivatives. Mechanistic studies allowed the isolation and characterization of key Ni0 and NiII catalytic intermediates. The Josiphos ligand is shown to play a key role in the stabilization of NiII intermediates to allow a Ni0/NiII catalytic pathway. Mechanistic understanding was then leveraged to improve the protocol using an air‐stable NiII pre‐catalyst.
A nickel/Josiphos‐based catalytic system is shown to be very efficient for the mono‐α‐arylation of acetone with (hetero)aryl chlorides and phenol derivatives. Broad functional‐group tolerance was observed, and the desired products were obtained in good to excellent yields. Mechanistic studies allowed the isolation of catalytic intermediates and provided a rationale for the key role of the ligand.
Graphisches Inhaltsverzeichnis: Angew. Chem. 43/2020
Berichtigung: A Dysprosium Metallocene Single‐Molecule Magnet Functioning at the Axial Limit
Berichtigung: Thiol–Anhydride Dynamic Reversible Networks