비스포스포네이트 투여와 관련된 양측성 대퇴골 전자하부 골절 1예의 장기간 추적 경과 = A Case Report of Bisphosphonate-associated Bilateral Subtrochanteric Femur Fracture and Long-term Follow-up

다국어 초록 (Multilingual Abstract)

Bisphosphonates have been used in the treatment of postmenopausal osteoporosis for many years. However, it has been concerned that long-term bisphosphonate therapy may lead to over-suppression of bone remodelling and increase skeletal fragility. Recently, atypical subtrochanteric femoral fractures are increasingly reported in patients on long-term treatment with bisphosphonates. We experienced a case of a 75-year-old woman who had a subtrochanteric femoral fracture after receiving long-term bisphosphonate therapy for osteoporosis. After more than 7 years of taking bisphosphonate, the patient developed left anterior thigh pain that was getting worse. A subtrochanteric insufficiency fracture of the left femur was demonstrated by radiographs. There was focally-increased uptake in both mid-femoral shaft by whole body bone scan. The lesion was recognized as pseudofracture. Bisphosphonate was discontinued and she underwent left intramedullary rod fixation. This patient had been treated with oral calcium, vitamin D, and raloxifene. She recovered without further complication.