wound healing activity of plumbagin and the chloroform extract of Plumbago rosea Linn. (Yoot),incorporated into ointments with yellow soft paraffin, have been investigated on rats. Wound healing activity wasstudied using excision and incision wound mo...
wound healing activity of plumbagin and the chloroform extract of Plumbago rosea Linn. (Yoot),incorporated into ointments with yellow soft paraffin, have been investigated on rats. Wound healing activity wasstudied using excision and incision wound models in rats following topical application. Both plumbagin and thePlumbago rosea root extract produced a significant response in both of the wound models studied. The woundPlumbago rosea root extract (0.5%),as against in 22 days in the case of control animals. The results were also comparable to those of a standard drug,framycetin sulphate cream (1% w/w) in terms of wound contracting ability, wound closure time, tensile strengthof wound and regeneration of tissues at the wound site. Histological studies revealed evidences for the healingprocess by formation of fibrovascular tissue, epithelization and increased collagenization when compared tocontrol.Keywordswound healing activity, Plumbago rosea, plumbagin, Plumbaginaceae