S-221 Diastolic dysfunction is much closely related with exercise intolerance in women = S-221 Diastolic dysfunction is much closely related with exercise intolerance in women

다국어 초록 (Multilingual Abstract)

Background: Diastolic dysfunction is independently related with exercise intolerance. We analyzed the relationship between left ventricular (LV) filling pressure and exercise capacity that was measured through treadmill exercise test (TMT). Methods: The data of 1589 patients (1155 women, mean age＝51.2±10.8 years) who presented with chest pain in outpatient clinic were analyzed. We evaluated and performed tests such as baseline blood tests including cardiac markers, TMT, echocardiography, coronary angiography (CAG), cardiac MRI and other imaging tests if indicated. We analyzed echocardiography and TMT results in these patients. First, we divided the patients into 2 groups according to the E/Ea of 13. Second, we estimated the exercise capacity with TMT test results (METs, total exercise time). Finally, we compared NT-proBNP, LV end diastolic dimension (LVEDD), LV end systolic dimension (LVESD), LV mass index (LVMI), LV ejection fraction (LVEF) and LV diastolic function such as E/Ea in each group to scrutinize the relationship among these values. Results: Work amount described by METs was higher for low E/Ea group (10.17±2.61 METs vs. 8.41±2.54 METs, p＜0.001). Total TMT exercise time was longer for low E/Ea group (8.02±2.5 minutes vs. 6.59±2.7 minutes, p＜0.001). NT-proBNP was higher in high E/Ea group (190.1±596.9 pg/mL vs. 1889.2±5720 pg/mL, p＝0.006). LVEDD was different between groups (46.49±5.03 mm in low E/Ea group vs. 47.52±6.14 mm in high E/Ea group, p＝0.01). LVESD was smaller in low E/Ea group (29.45±5.58 mm vs. 31.11±8.07 mm, p＝0.002). LVMI was also significantly smaller in low E/Ea group (87.82±28.9 g/m2 vs. 98.15±35.94 g/m2, p＜0.001). However, LVEF was not significantly different between two groups (61.67±6.82 % in low E/Ea group vs. 60.94±10.38 % in high E/Ea group, p＝0.170). When the data was analyzed according to sex, the results were still meaningful in both sex. The relation between diastolic dysfunction and exercise capacity was much stronger in women than in men. Conclusion Diastolic dysfunction was closely related with exercise capacity in both men and women. However, the relation was much stronger in women than in men.