마우스에서 흑지마 에탄올 추출물의 기억력 증진 효과 및 기억력 감퇴에 대한 개선 효과 = Memory Enhancing Properties of the Ethanolic Extract of Black Sesame and its Ameliorating Properties on Memory Impairments in Mice

다국어 초록 (Multilingual Abstract)

Black sesame (Sesami semen nigrum) has been used to treat dizziness, earnoise, constipation in the traditional Chinese medicine. In the present study, we assessed memory enhancing properties of 70% ethanolic extract of black sesame (EBS70) and its ameliorating activities on learning and memory impairments induced by scopolamine. Drug-induced amnesia was made by scopolamine treatment (1 mg/kg, i.p.). Single EBS70 (200 mg/kg, p.o.) administration significantly enhanced cognitive function and attenuated scopolamine-induced cognitive impairments as determined by the passive avoidance and Y-maze tasks (P<0.05) and also reduced escape-latency on the Morris water maze task (P<0.05). In addition, EBS70 increased BDNF expression in hippocampus 4 h after its administration (P<0.05). These results suggest that EBS70 enhances learning and memory in normal state and attenuates amnesic state caused by cholinergic dysfunction.

참고문헌 (Reference)

1 대한민국 특허, "등록번호 10-0560175. 세사미놀 배당체 또 는 이를 포함하는 참깨 추출물을 함유하는 치매 예방 및 치료용 기능성 식품 조성물"

2 Kennedy, D. O, "The psychopharmacology of European herbs with cognition-enhancing properties" 12 : 4613-4623, 2006

3 Ramarathnam, N., "The contribution of plant food antioxidants to human health" 6 : 75-82, 1995

4 Shim, Y. H., "Studies on the experimental cookery and the preservation of the Hukimja Dashik" 6 : 13-26, 1995

5 Um, M. Y., "Sesaminol glucosides protect â-amyloid peptideinduced cognitive deficts in mice" 32 : 1516-1520, 2009

6 Evans, D. A., "Prevalence of Alzheimer's disease in a community population of older persons" 262 : 2551-2556, 1989

7 Howes, M. J., "Plants with traditional uses and activities,relevant to the management of Alzheimer's disease and other cognitive disorders" 17 : 1-18, 2003

8 Nordberg,A, "Pharmacological treatment of cognitive dysfunction in dementia disorders.Acta Neurol.Scand" 168 : 87-92, 1996

9 Huang, E. J, "Neurotrophins:roles in neuronal development and function" 24 : 677-736, 2001

10 Myhrer,T, "Neurotransmitter systems involved in learning and memory in the rat:a meta-analysis based on studies of four behavioral tasks" 41 : 268-287, 2003

11 Kuhl, D. E., "In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer’s disease" 52 : 691-699, 1999

12 Kennedy, D. O, "Ginseng:potential for the enhancement of cognitive performance and mood" 75 : 687-700, 2003

13 LeDoux,J.E, "Emotional memory systems in the brain" 58 : 69-79, 1993

14 Rosler, M., "Efficacy and safety of rivastigmine in patients with Alzheimer’s disease,international randomized controlled trial" 318 : 633-638, 1999

15 Morris,R.G, "Development of a water maze procedure for studying spatial learning in the rat" 11 : 47-60, 1984

16 Bekinschtein, P., "BDNF is essential to promote persistence of long-term memory storage" 105 : 2711-2716, 2008

17 Bramham, C. R, "BDNF function in adult synaptic plasticity:the synaptic consolidation hypothesis" 76 : 99-125, 2005

18 Sarter, M., "Attenuation of scopolamine-induced impairment of spontaneous alteration behaviour by antagonist but not inverse agonist and agonist beta-carbolines" 94 : 491-495, 1988

19 Shyu, Y. S, "Antioxidative activity of the crude extract of lignan glycosides from unroasted Burma black sesame meal" 35 : 357-365, 2002

20 Blokland,A, "Acetylcholine:a neurotransmitter for learning and memory? Brain Res" 21 : 285-300, 1995

21 Davis, K. L., "A double-blind placebo-controlled multicenter study of Tacrine for Alzheimer’s disease" 327 : 1253-1259, 1992

22 Acheson, A., "A BDNF autocrine loop in adult sensory neurons prevents cell death" 374 : 450-453, 1995

23 Tariot, P. N., "A 5-month,randomized,placebo-controlled Trial of galantamine in AD,Th Galantamine USA-10 Study Group" 54 : 2269-2276, 2000

24 Rogers, S. L., "A 24-week,double-blind,pacebo-controlled trial of donepezil in patients with Alzheimer’s disease" 50 : 136-145, 1998