Adrenocorticotropic Hormone-Secreting Esthesioneuroblastoma with Ectopic Cushing’s Syndrome

다국어 초록 (Multilingual Abstract)

Esthesioneuroblastoma as a source of ectopic Cushing’s syndrome is rare, and to the best of our knowledge, only 20 cases havebeen reported worldwide. A 46-year-old healthy man visited a local clinic for general weakness and hyposmia, and underwentexamination with serial endocrinological workup and brain imaging. 68Gallium-DOTA-TOC positron emission tomography scanwas helpful where diagnosis of sellar MRI and inferior petrosal sinus sampling were discordant. Combined transcranial and endoscopicendonasal approach surgery was performed, and a diagnosis of esthesioneuroblastoma was given.

참고문헌 (Reference)

1 Porter AB, "Retrospective review of adjuvant chemotherapy for esthesioneuroblastoma" 90 : 201-204, 2008

2 Young J, "Pitfall of petrosal sinus sampling in a Cushing’s syndrome secondary to ectopic adrenocorticotropin-corticotropin releasing hormone(ACTH-CRH)secretion" 83 : 305-308, 1998

3 Kanno K, "Olfactory neuroblastoma causing ectopic ACTH syndrome" 52 : 675-681, 2005

4 Reznik M, "Neuroendocrine tumor of the nasal cavity(esthesioneuroblastoma). Apropos of a case with paraneoplastic Cushing’s syndrome" 7 : 137-142, 1987

5 Yamamoto Y, "False-positive inferior petrosal sinus sampling in the diagnosis of Cushing’s disease. Report of two cases" 83 : 1087-1091, 1995

6 Freeman SR, "Expression of somatostatin receptors in arginine vasopressin hormone-secreting olfactory neuroblastoma--report of two cases" 43 : 61-65, 2005

7 Gallia GL, "Endonasal endoscopic resection of olfactory neuroblastoma : an 11-year experience" 131 : 238-244, 2018

8 Kadoya M, "Ectopic adrenocorticotropic hormone syndrome associated with olfactory neuroblastoma : acquirement of adrenocorticotropic hormone expression during disease course as shown by serial immunohistochemistry examinations" 46 : 4760-4768, 2018

9 Josephs L, "Cushing’s syndrome : an unusual presentation of olfactory neuroblastoma" 18 : 73-76, 2008

10 Hofmann M, "Biokinetics and imaging with the somatostatin receptor PET radioligand(68)Ga-DOTATOC : preliminary data" 28 : 1751-1757, 2001

11 Han JY, "Bilateral adrenalectomy : lifesaving procedure in severe Cushing syndrome" 18 : e85-e90, 2012

12 Familiar C, "Adrenocorticotropic hormone-dependent Cushing syndrome caused by an olfactory neuroblastoma" 12 : 1179551419825832-, 2019

13 Bouche J, "A further case of tumor of the olfactory placode" 43 : 587-591, 1967

14 Chen SH, "68Ga-DOTATOC and 18F-FDG PET/CT for identifying the primary lesions of suspected and metastatic neuroendocrine tumors : A prospective study in Taiwan" 117 : 480-487, 2018