<P>21-O-Angeloyltheasapogenol E3 (ATS-E3) is a triterpenoid saponin recently isolated from the seeds of the tea tree <I>Camellia sinensis</I> (L.) O. Kuntze. ATS-E3 has several beneficial properties including anti-inflammatory, antid...
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https://www.riss.kr/link?id=A107708392
2014
-
SCOPUS,SCIE
학술저널
658351
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>21-O-Angeloyltheasapogenol E3 (ATS-E3) is a triterpenoid saponin recently isolated from the seeds of the tea tree <I>Camellia sinensis</I> (L.) O. Kuntze. ATS-E3 has several beneficial properties including anti-inflammatory, antid...
<P>21-O-Angeloyltheasapogenol E3 (ATS-E3) is a triterpenoid saponin recently isolated from the seeds of the tea tree <I>Camellia sinensis</I> (L.) O. Kuntze. ATS-E3 has several beneficial properties including anti-inflammatory, antidiabetic, antiatherosclerotic, and anticancer effects. Unlike other phenolic compounds isolated from tea plants, there are no studies reporting the pharmacological action of ATS-E3. In this study, we therefore aimed to explore the cellular and molecular inhibitory activities of ATS-E3 in macrophage-mediated inflammatory responses. ATS-E3 remarkably diminished cellular responses of macrophages such as FITC-dextran-induced phagocytic uptake, sodium nitroprusside- (SNP-) induced radical generation, and LPS-induced nitric oxide (NO) production. Analysis of its molecular activity showed that this compound significantly suppressed the expression of inducible NO synthase (iNOS), nuclear translocation of nuclear factor- (NF-) <I>κ</I>B subunits (p50 and p65), phosphorylation of inhibitor of <I>κ</I>B kinase (IKK), and the enzyme activity of AKT1. Taken together, the novel triterpenoid saponin compound ATS-E3 contributes to the beneficial effects of tea plants by exerting anti-inflammatory and antioxidative activities in an AKT/IKK/NF-<I>κ</I>B-dependent manner.</P>