Coronary Artery Calcium Score and Bone Metabolism: A Pilot Study in Postmenopausal Women|RISS 상세보기

다국어 초록 (Multilingual Abstract)

Background: Since 1991 many studies evaluated the link between cardiovascular diseases and osteoporosis, two age-related conditions, but the main common pathologic pathway has not been determined yet. The histological similarity between arterial calcified plaque and bone matrix and involvement of similar cells and mediators provide a special field of research. Therefore in the present study, we aimed to evaluate the relationship between coronary artery calcium score (CACS) as a surrogate marker of atherosclerosis and bone mediators and parameters in postmenopausal women. Methods: Eleven postmenopausal women who had CACS higher than 80 were enrolled into the study and underwent bone densitometry. In addition, their serum and urine samples were taken for measuring osteoprotegerin, osteocalcin, and β cross laps. Patients’ 10- year probability of fracture was calculated by the World Health Organization fracturerisk assessment tool (FRAX). Results: The regression analysis of our results showed the association between CACS and OC (std β=0.66, 95% confidence interval [CI] 5.47-72.27, P=0.027), femoral bone density (std β=-0.6, 95% CI -6864.34-14.27, P=0.05) and T-score (std β=-0.6, 95% CI -773.08-1.28, P=0.05) which remained significant after adjustment for age, weight, years since menopause and body mass index. No association was found between CACS and osteoprotegerin, spinal bone density and FRAX score. Conclusions: In conclusion, this pilot study with small sample size showed the potential association between CACS and osteocalcin, femoral bone density and T-score. However, the relationship between CACS and osteoprotegerin, receptor activator of nuclear factor-kappa B ligand, FRAX score and other bone parameters remain to be clarified in larger sample size studies.

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참고문헌 (Reference)

1 Farhat GN, "Volumetric BMD and vascular calcification in middle-aged women: the Study of Women's Health Across the Nation" 21 : 1839-1846, 2006

2 Jono S, "Serum osteoprotegerin levels are associated with the presence and severity of coronary artery disease" 106 : 1192-1194, 2002

3 Asanuma Y, "Serum osteoprotegerin is increased and independently associated with coronary-artery atherosclerosis in patients with rheumatoid arthritis" 195 : e135-e141, 2007

4 Ogawa-Furuya N, "Serum osteocalcin levels are inversely associated with abdominal aortic calcification in men with type 2 diabetes mellitus" 24 : 2223-2230, 2013

5 Sheng L, "Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes" 12 : 22-, 2013

6 Bao Y, "Serum levels of osteocalcin are inversely associated with the metabolic syndrome and the severity of coronary artery disease in Chinese men" 75 : 196-201, 2011

7 Celik C, "Relationship between decreased bone mineral density and subclinical atherosclerosis in postmenopausal women" 13 : 254-258, 2010

8 Collin-Osdoby P, "Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin" 95 : 1046-1057, 2004

9 Quercioli A, "Receptor activator of nuclear factor kappa B ligand/osteoprotegerin pathway is a promising target to reduce atherosclerotic plaque calcification" 9 : 227-230, 2010

10 Agatston AS, "Quantification of coronary artery calcium using ultrafast computed tomography" 15 : 827-832, 1990