Poster Session : PS 1055; Gastroenterology (Gastrointestinal Tract) ; The Effect of H. pylori Eradication on Metachronous Gastric Neoplasms after Endoscopic Resection of Gastric Dysplasia = Poster Session : PS 1055; Gastroenterology (Gastrointestinal Tract) ; The Effect of H. pylori Eradication on Metachronous Gastric Neoplasms after Endoscopic Resection of Gastric Dysplasia

다국어 초록 (Multilingual Abstract)

Background: Helicobater pylori (H. pylori ) infection was closely related in gastric atrophy, intestinal metaplasia, and a progression to dysplasia or cancer. Furthermore, some studies showed that eradication of H. pylori after endoscopic resection (ER) of early gastric cancer could prevent the development of metachronous gastric cancer. However, there are no suffi cient data about the role of eradication of H. pylori after ER for gastric dysplasia. The aim of this study was to investigate the effect of H. pylori eradication would affect the development of the metachronous gastric neoplasms after ER in patients with gastric dysplasia. Methods: We retrospectively reviewed 1872 patients who underwent endoscopic resection of gastric dysplasia from January 2007 to February 2012 at Severance hospital. We excluded patients with follow-up period of < 2 years and who had not undergone tests for active H. pylori infection at the time of endoscopy. Total of 282 patients were enrolled in this study. Then divided them into three groups: those without active H. pylori infection (Hp negative group, n=124), those who successfully underwent H. pylori eradication (eradicated group, n=122), and those who failed or did not undergo H. pylori eradication (non-eradicated group, n=36). The rate of metachronous recurrence after ER was compared. Results: Metachronous reccurence was diagnosed in 36 patients, including 19 in the Hp negative, 10 in the eradicated, 7 in the non-eradicated group. Median time to recurrence was 22 months (range, 6-65 months). The incidence was 4. 18, 1. 93, 5. 0 cases per 1,000 person-years in the Hp negative, eradicated, noneradicated group, respectively. Patients in non-eradicated group had a higher risk of developing metachronous gastric neoplasms than eradicated group (HR 2. 671, p=0. 047). Conclusions:The successful H. pylori eradication may reduce the development metachronous gastric neoplasms after ER in patients with gastric dysplasia.