The aerial parts of Houttuynia cordata used for treating inflammation-related disorders contain flavonoids as major constituents. Since certain flavonoids possess antiinflammatory activity, especially in the lung, the pharmacological activities of...
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https://www.riss.kr/link?id=A104665085
2015
English
KCI등재,SCIE,SCOPUS
학술저널
1304-1311(8쪽)
17
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
The aerial parts of Houttuynia cordata used for treating inflammation-related disorders contain flavonoids as major constituents. Since certain flavonoids possess antiinflammatory activity, especially in the lung, the pharmacological activities of...
The aerial parts of Houttuynia cordata used for treating inflammation-related disorders contain flavonoids as major constituents. Since certain flavonoids possess antiinflammatory activity, especially in the lung, the pharmacological activities of H. cordata and the flavonoid constituents were evaluated using in vitro and in vivo models of lung inflammation. The 70 % ethanol extract of the aerial parts of H. cordata inhibited the production of inflammatory biomarkers IL-6 and NO in lung epithelial cells (A549) and alveolar macrophages (MH-S), respectively. And the same plant material, administered orally (100 and 400 mg/kg), significantly inhibited lung inflammatory response in a mouse model of lipopolysaccharide (LPS)-induced acute lung injury. From the extract, major flavonoids including afzelin, hyperoside and quercitrin were successfully isolated and they also attenuated LPS-induced lung inflammation in mice by oral administration. In particular, quercitrin showed most potent activity at 100 mg/kg. These results demonstrate for the first time that H. cordata and three flavonoid constituents have a therapeutic potential for treating lung inflammatory disorders.
참고문헌 (Reference)
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8 Ganesan, S., "Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression" 11 : 131-, 2010
9 Guan, Y., "Protective effects of liquiritigenin apioside on cigarette smoke-induced lung epithelial cell injury" 26 : 473-483, 2012
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1 Chen, J., "Total flavonoids of Mosla acabra leaves attenuate lipopolysaccharide-induced acute lung injury via down-regulation of inflammatory signaling n mice" 148 : 835-841, 2013
2 Lim, H.J., "The root barks of Morus alba and the flavonoid constituents inhibit airway inflammation" 149 : 169-175, 2013
3 Bae, K., "The medicinal plants of Korea" Kyo-Hak Publishing Company 160-, 2000
4 Kim, I.S., "The inhibitory effect of Houttuynia cordata extract on stem cell factor-induced HMC-1 cell migration" 112 : 90-95, 2007
5 Lu, H.M., "Tentative fingerprint-efficacy study of Houtuynia cordata injection in quality control of traditional Chinese medicine" 54 : 725-730, 2006
6 Lago, J.H.G., "Structureactivity association of flavonoids in lung diseases" 19 : 3570-3595, 2014
7 Mossman, T., "Rapid colorimetric assay for cellular growth and survival : application to proliferation and cytotoxic assays" 65 : 55-63, 1983
8 Ganesan, S., "Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression" 11 : 131-, 2010
9 Guan, Y., "Protective effects of liquiritigenin apioside on cigarette smoke-induced lung epithelial cell injury" 26 : 473-483, 2012
10 고현정, "Inhibition of Experimental Lung Inflammation and Bronchitis by Phytoformula Containing Broussonetia papyrifera and Lonicera japonica" 한국응용약물학회 19 (19): 324-330, 2011
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학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2023 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2020-01-01 | 평가 | 등재학술지 유지 (해외등재 학술지 평가) | |
2010-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2008-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2006-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2004-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2001-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
1998-07-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 1.96 | 0.2 | 1.44 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
1.07 | 0.87 | 0.439 | 0.05 |