Effect of acute intradialytic strength physical exercise on oxidative stress and infiammatory responses in hemodialysis patients = Effect of acute intradialytic strength physical exercise on oxidative stress and infiammatory responses in hemodialysis patients

다국어 초록 (Multilingual Abstract)

Background: Oxidative stress and in.ammation are common .ndings in chronic kidney disease (CKD) patients, and they are directly related to the increased risk of developing cardiovascular disease, which is the major cause of death in these patients, particularly for those undergoing hemodialysis (HD). Strength physical exercise is a new therapeutic approach to reduce these complications in CKD patients. Following this, the purpose of this study was to assess the effect of acute intradialytic strength physical exercise on oxidative stress and in.ammatory responses in HD patients. Methods: Sixteen HD patients were studied (11 women; 44.4714.6 years; body mass index 23.374.9 kg/m2; 61.6743.1 months of dialysis) and served as their own controls. Acute (single session) intradialytic physical exercise were performed at 60% of the onerepetition maximum test for three sets of 10 repetitions for four exercise categories in both lower limbs during 30 minutes. Blood samples were collected on two different days at exactly the same time (30 minutes and 60 minutes after initiating the dialysis-with and without exercise). Antioxidant enzymes activity [superoxide dismutase (SOD), catalase, and glutathione peroxidase], lipid peroxidation marker levels (malondialdehyde), and in.ammatory marker levels (high-sensitivity C-reactive protein) were determined. Results: SOD plasma levels were signi.cantly reduced after acute physical exercise from 244.8740.7 U/mL to 222.4728.9 U/mL (P¼0.03) and, by contrast, increased on the day without exercise (218.2726.5 U/mL to 239.4738.6 U/mL, P¼0.02). There was no alteration in plasma catalase, glutathione peroxidase, malondialdehyde, or highsensitivity C-reactive protein levels in on either day (with or without exercise). Additionally, there was no association between these markers and clinical, anthropometric, or biochemical parameters. Conclusion: These data suggest that acute intradialytic strength physical exercise was unable to reduce oxidative stress and in.ammation, and in addition, it seems to reduce plasma SOD levels, which could exacerbate the oxidative stress in HD patients. Copyright & 2015. The Korean Society of Nephrology. Published by Elsevier. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).