중량당 섬유수가 다른 국내산 석면이 폐 기능과 폐 조직에 미치는 영향 평가 = Effect of Fiber Number Per Mass Concentration in Korean Produced Asbestos on Lung Function and Pathology

다국어 초록 (Multilingual Abstract)

Objectives: To evaluate the pulmonary toxicity of 2 Korea asbestos(chrysotile, anthophyllite), Sprague-Dawely rats were exposed to 2 mg domestic asbestos by intratracheal instillation(IT). Methods: Lung function of rats was analyzed by pressure transducer(MAX1320, Buxco Electronics, USA). The effects of 2 mg asbestos(chrysotile; 8,814,244 × 106 fibers/mg, average diameter 0.08 μm, average length 4.39 μm, anthophyllite; 5,182 × 106 fibers/mg, average diameter 0.95 μm, average length 7.29 μm) on pulmonary function and pathological changes were evaluated at after a single IT. Lung function and histopathological evaluation were assessed in 5 animals from each group at each time point. Results: Due to differences in fiber numbers, chrysotile induce marked lung pathology and lung function change than anthophyllite at the same mass dose. Chrysotile showed notable thickening of interstitial areas surrounding the alveolar ducts and terminal bronchioles. Conclusions: On a mass dose basis, chrysotile that have 1,700 times numbers of fibers per unit weight than anthophyllite produced a greater persistent lung injury than anthophllite for at least 4 weeks after exposure.

참고문헌 (Reference)

1 한국환경공단, "석면피해구제제도 업무매뉴얼"

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