혈액투석 환자에서 ApoE 유전자 다형성과 혈청 지질에 대한 연구 = Relationship between Apolipoprotein E Polymorphism end Serum lipid Profiles in Hemodialysis patients

다국어 초록 (Multilingual Abstract)

Apolipoprotein(apo) E polymorphism consists of there major groups (E2, E3, and E4). Because of their difference in a lipid-modulating effect, the polymorphism has been reported to affect the morbidity of atherosclerosis in general population. Therefore, in hemodialysis patients, the apo E polymorphism may also modulate serum levels of cholesterol. We determined apo E phenotypes in 45 HD patients and 51 controls. We measured postprandial serum levels of lipids in the dialysis patients. We found a similar phenotype distribution and allele frequency between hemodialysis patients and healthy controls. Serum levels of total cholesterol, and triglyceride did not differ significantly among patients with apo E groups. Patients with apo E4 had significantly lower levels of high-density lipoprotein cholesterol, significantly higher levels of low-density lipoprotein cholesterol(LDL-C) than those with apo E2 (P<0.05).
Apo E polymorphism modulates cholesterol metabolism in dialysis patients but appears to have little association with the prevalence of cerebrovascular complications in the patients.