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      KCI등재 SCOPUS SCIE

      Ependymal Cells Require Anks1a for Their Proper Development

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      https://www.riss.kr/link?id=A106096703

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      다국어 초록 (Multilingual Abstract)

      Ependymal cells constitute the multi-ciliated epithelium, which lines the brain ventricular lumen. Although ependymal cells originate from radial glial cells in the perinatal rodent brain, the exact mechanisms underlying the full differentiation of ependymal cells are poorly understood. In this report, we present evidence that the Anks1a phosphotyrosine binding domain (PTB) adaptor is required for the proper development of ependymal cells in the rodent postnatal brain. Anks1a gene trap targeted LacZ reporter analysis revealed that Anks1a is expressed prominently in the ventricular region of the early postnatal brain and that its expression is restricted to mature ependymal cells during postnatal brain development. In addition, Anks1a-deficient ependymal cells were shown to possess type B cell characteristics, suggesting that ependymal cells require Anks1a in order to be fully differentiated. Finally, Anks1a overexpression in the lateral wall of the neonatal brain resulted in an increase in the number of ependymal cells during postnatal brain development. Altogether, our results suggest that ependymal cells require Anks1a PTB adaptor for their proper development.
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      Ependymal cells constitute the multi-ciliated epithelium, which lines the brain ventricular lumen. Although ependymal cells originate from radial glial cells in the perinatal rodent brain, the exact mechanisms underlying the full differentiation of ep...

      Ependymal cells constitute the multi-ciliated epithelium, which lines the brain ventricular lumen. Although ependymal cells originate from radial glial cells in the perinatal rodent brain, the exact mechanisms underlying the full differentiation of ependymal cells are poorly understood. In this report, we present evidence that the Anks1a phosphotyrosine binding domain (PTB) adaptor is required for the proper development of ependymal cells in the rodent postnatal brain. Anks1a gene trap targeted LacZ reporter analysis revealed that Anks1a is expressed prominently in the ventricular region of the early postnatal brain and that its expression is restricted to mature ependymal cells during postnatal brain development. In addition, Anks1a-deficient ependymal cells were shown to possess type B cell characteristics, suggesting that ependymal cells require Anks1a in order to be fully differentiated. Finally, Anks1a overexpression in the lateral wall of the neonatal brain resulted in an increase in the number of ependymal cells during postnatal brain development. Altogether, our results suggest that ependymal cells require Anks1a PTB adaptor for their proper development.

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      참고문헌 (Reference)

      1 Manzini, M. C., "What disorders of cortical development tell us about the cortex : One plus one does not always make two" 21 : 333-339, 2011

      2 Mirzadeh, Z., "The subventricular zone en-face: Wholemount staining and ependymal flow" 6 : 1938-, 2010

      3 Kriegstein, A., "The glial nature of embryonic and adult neural stem cells" 32 : 149-184, 2009

      4 Spassky, N., "The development and functions of multiciliated epithelia" 18 : 423-436, 2017

      5 Kim, J., "The SAM domains of anks family proteins are critically involved in modulating the degradation of EphA receptors" 30 : 1582-1592, 2010

      6 De Rubeis, S., "Synaptic, transcriptional and chromatin genes disrupted in autism" 515 : 209-215, 2014

      7 Uhlik, M. T., "Structural and evolutionary division of phosphotyrosine binding(PTB)domains" 345 : 1-20, 2005

      8 Lavado, A., "Six3 is required for ependymal cell maturation" 138 : 5291-5300, 2011

      9 Codega, P., "Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche" 82 : 545-559, 2014

      10 Noh, H., "Proper closure of the optic fissure requires ephrin A5-EphB2-JNK signaling" 143 : 461-472, 2016

      1 Manzini, M. C., "What disorders of cortical development tell us about the cortex : One plus one does not always make two" 21 : 333-339, 2011

      2 Mirzadeh, Z., "The subventricular zone en-face: Wholemount staining and ependymal flow" 6 : 1938-, 2010

      3 Kriegstein, A., "The glial nature of embryonic and adult neural stem cells" 32 : 149-184, 2009

      4 Spassky, N., "The development and functions of multiciliated epithelia" 18 : 423-436, 2017

      5 Kim, J., "The SAM domains of anks family proteins are critically involved in modulating the degradation of EphA receptors" 30 : 1582-1592, 2010

      6 De Rubeis, S., "Synaptic, transcriptional and chromatin genes disrupted in autism" 515 : 209-215, 2014

      7 Uhlik, M. T., "Structural and evolutionary division of phosphotyrosine binding(PTB)domains" 345 : 1-20, 2005

      8 Lavado, A., "Six3 is required for ependymal cell maturation" 138 : 5291-5300, 2011

      9 Codega, P., "Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche" 82 : 545-559, 2014

      10 Noh, H., "Proper closure of the optic fissure requires ephrin A5-EphB2-JNK signaling" 143 : 461-472, 2016

      11 Kuo, C. T., "Postnatal deletion of numb/numblike reveals repair and remodeling capacity in the subventricular neurogenic niche" 127 : 1253-1264, 2006

      12 Bayly, R., "Pointing in the right direction : New developments in the field of planar cell polarity" 12 : 385-391, 2011

      13 Ohata, S., "Planar organization of multiciliated ependymal(E1)cells in the brain ventricular epithelium" 39 : 543-551, 2016

      14 Neale, B. M., "Patterns and rates of exonic de novo mutations in autism spectrum disorders" 485 : 242-245, 2012

      15 Tong, J., "Odin(ANKS1A)modulates EGF receptor recycling and stability" 8 : e64817-, 2013

      16 Feliciano, D. M., "Neonatal subventricular zone electroporation" 11 : 50197-, 2013

      17 Ihrie, R. A., "Lake-front property : A unique germinal niche by the lateral ventricles of the adult brain" 70 : 674-686, 2011

      18 Tissir, F., "Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus" 13 : 700-707, 2010

      19 Sunjung Park, "In Vivo Expression of the PTB-deleted Odin Mutant Results in Hydrocephalus" Korean Society for Molecular and Cellular Biology 38 (38): 426-431, 2015

      20 Shin, J., "Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function" 27 : 8113-8126, 2007

      21 Jacquet, B. V., "FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain" 136 : 4021-4031, 2009

      22 Carlen, M., "Forebrain ependymal cells are notch-dependent and generate neuroblasts and astrocytes after stroke" 12 : 259-267, 2009

      23 Holmberg, J., "Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis" 19 : 462-471, 2005

      24 Conover, J. C., "Disruption of eph/ephrin signaling affects migration and proliferation in the adult subventricular zone" 3 : 1091-1097, 2000

      25 Fromer, M., "De novo mutations in schizophrenia implicate synaptic networks" 506 : 179-184, 2014

      26 Guirao, B., "Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia" 12 : 341-350, 2010

      27 Mirzadeh, Z., "Cilia organize ependymal planar polarity" 30 : 2600-2610, 2010

      28 Lee, H., "Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis" 7 : 12799-, 2016

      29 Paez-Gonzalez, P., "Ank3-dependent SVZ niche assembly is required for the continued production of new neurons" 71 : 61-75, 2011

      30 Spassky, N., "Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis" 25 : 10-18, 2005

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      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2012-11-07 학술지명변경 한글명 : 분자와 세포 -> Molecules and Cells KCI등재
      2008-01-01 평가 SCI 등재 (등재유지) KCI등재
      2006-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2004-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2001-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      1998-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 2.77 0.19 1.85
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      1.37 1.11 0.379 0.03
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