Efficacy of gastro-retentive forms of ecabet sodium in the treatment of gastric ulcer in rats

다국어 초록 (Multilingual Abstract)

The purpose of the present study is to investigatethe influence of gastric retention of ecabet sodium(ECS) on its mucoprotective effect in rat ulcer models.
Mini-tablets containing 9 mg ECS were prepared using thedirect compression method. The release rates of ECS minitabletswere controlled by the amount and viscosity gradeof hydroxypropylmethyl cellulose incorporated. Gastricretention of ECS mini-tablets after oral administration torats was visually confirmed using a fluorescence imagingsystem. Because ECS mini-tablets exhibited size-dependentgastric retention, their gastric retention time wasprolonged as the release rate decreased. In the in vivoefficacy study, gastro-retentive dosage forms of ECS didnot influence the mucoprotective effect in the immediateirritation model but enhanced the effect in the delayedirritation model compared with ECS suspension. Thisfinding indicates that the duration of the mucoprotectiveeffect of ECS can be extended by the employment ofgastro-retentive dosage formulations and provides a rationalefor development of ECS gastro-retentive dosageforms.

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