Methanol Extract of Agaricus blazei Murill Reduces Hepatic Damage Induced by CCl₄ and High Fat and Improves Liver Lipid Profile in Rats

다국어 초록 (Multilingual Abstract)

??The effect of methanol extract from Agaricus blazei Murill on the hepatotoxicity was investigated CCl₄is one of the oldest and most widely used toxins for the induction of hepatic damages and fibrosis in experimental animals. In this study, male Sprague-Dawley(SD) rats were randomly divided into 6 groups of the control(C), CCl₄(T), CCl₄and high fat group(TL) with matching sub-groups of Agaricus blazei Murill extract-fed groups of CA, TA and TLA. Methanol extracts of Agaricus blazei Murill were fed 50 ㎎/㎏ B.W daily via drinking water. A 1.2 ㎖ of CCl₄/㎏ body weight was administered by oral intubation twice a week for total of six times. The levels of total-cholesterol, TG, LDL and LDL-phospholipids were elevated by CCl₄treatment as compared to the control(C). However, Agaricus blazei Murill methanol extract feeding in the group of TA and TLA significantly(p＜0.05) decreased TG by 53.1% and 17.9% compared to the internal control of T and TL, respectively. Triglyceride of TL was increased by 3.33 times(p＜0.05) compared to the control(C) with CCl₄and high fat administration from 3.78 ㎎/g to 12.60㎎/g liver. The extract(CA) also reduced kidney weight compared to the control(C). With the administration of high fat and CCl₄(TLA), the extract reduced the organ weight of both liver and kidney and further, significantly reduced TG, total cholesterol and GTP activity. Hepatoprotective effects of Agaricus blazei Murill on GOT, GPT, AP and LDH activities were enhanced by the extract feeding. Electronmicrograph showed that CCl₄deteriorated the structure of cytoplasmic matrix with its uneven distribution. However, the extract reconstituted the damaged cytoplasm and stimulated mitochondriogenesis. The above results suggest that Agaricus blazei Murill may have a possible protective effect against chemically induced liver damage and further help to reduce the symptoms of fatty liver.

목차 (Table of Contents)

• INTRODUCTION
• MATERIALS AND METHODS
• RESULTS AND DISCUSSION
• SUMMARY AND CONCLUSION
• Literature Cited