외부 민감형 탄소형광소재가 캡슐화된 무기나노입자 제조 및 암세포 치료 연구 = Stimuli-responsive Carbon Dots Encapsulated Inorganic Nanoparticles for Theragnosis

다국어 초록 (Multilingual Abstract)

In recent years, fluorescence carbon dots (CD) have gained recognition due to the ability to incorporate drugs and excellent luminescence characteristic. However, further development such as functionalizing the CD structure or integrate it with an inorganic material is necessary to obtain a stimuli-responsive nanoparticle with desirable drug loading capacity. Here, we developed a drug delivery system based on a hybrid fluorescence carbon dots-inorganic nanomaterial which applied for stimuli-responsive bioimaging and nanocarrier. In the first study, we utilized the used of MnO2 as a quenching effect to increase the selectivity of biocompatible Hyaluronic Acid (HA) carbon dots to redox environment. For another study, we optimize the high pore volume of mesoporous silica nanoparticle (MSN) by encapsulated zwitterion CD and photosensitizer to achieve a pH-responsive nanoparticle. Both systems displayed sensitivity toward cancer environment which showed a promising potential for tumor diagnosis and therapy.

목차 (Table of Contents)

• Overall introduction 1
• Chapter Ⅰ. Selective Redox-Responsive Theragnosis Nanocarrier for Breast Tumor Cells Mediated by MnO2/Fluorescent Carbon Nanogel 3
• I. Introduction 4
• II. Objective 7
• III. Experimental Section 9
• IV. Results and Discussion 15
• V. Conclusion 34
• VI. Abstract 35
• Chapter Ⅱ. Zwitterionic Carbon Dot-Encapsulated pH-Responsive Mesoporous Silica Nanoparticles for NIR Light-Triggered Photothermal Therapy through pH Controllable Release 36
• I. Introduction 37
• II. Objective 40
• III. Experimental Section 42
• IV. Results and Discussion 48
• V. Conclusion 64
• VI. Abstract 65