Effect of Eucommia ulmoides cortex extract on Ovariectomized rat model of Osteoporosis

다국어 초록 (Multilingual Abstract)

In the present study, we examined the preventive effects of the E. ulmoides on bone lose in OVX rat. E. ulmoides was administrated orally, which started on the first week after bilaterial OVX surgery. BMD was determined using dual energy x-ray absorptiometry (DXA).
Our finding demonstrated that 8 week treatment with E. ulmoides significantly increased femur and lumbar vertebrae bone mineral density (BMD) and inhibited the increase in serum alkaline phosphatase (ALP) levels compared to ovariectomized (OVX) control rats, without resulting in an increased uterus weight.
In conclusion, E. ulmoides is able to prevent OVX-induced in BMD without hyperplastic effect on uterus. E. ulmoides may be a reasonable natural alternative for the prevention of postmenopausal osteoporosis.

목차 (Table of Contents)

• I. Introduction 1
• II. Material and Methods 3
• 1. Preparation of E. ulmoides 3
• 2. Animals and treatments 3
• 3. BMD measurements 4
• 4. Assay for serum chemistry 4
• 5. Statistical analysis 4
• III. Results 5
• 1. Bone mineral density of the femur and lumbar vertebrae 5
• 2. Body weights 8
• 3. Organ weights 10
• 4. Serum chemistry 12
• IV. DISCUSSION 14
• REFERENCES 17
• ABSTRACT 20