<P><B>Abstract</B></P> <P>The infection caused by <I>Pseudomonas aeruginosa</I> is a serious concern in human health. The bacterium is an opportunistic pathogen which has been reported to cause nosocomial and...
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https://www.riss.kr/link?id=A107426574
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2019
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SCI,SCIE,SCOPUS
학술저널
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0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P><B>Abstract</B></P> <P>The infection caused by <I>Pseudomonas aeruginosa</I> is a serious concern in human health. The bacterium is an opportunistic pathogen which has been reported to cause nosocomial and...
<P><B>Abstract</B></P> <P>The infection caused by <I>Pseudomonas aeruginosa</I> is a serious concern in human health. The bacterium is an opportunistic pathogen which has been reported to cause nosocomial and chronic infections through biofilm formation and synthesis of several toxins and virulence factors. Furthermore, the formation of biofilm by <I>P. aeruginosa</I> is known as one of the resistance mechanisms against conventional antibiotics. Natural compounds from marine resources have become one of the simple, cost-effective, biocompatible and non-toxicity for treating <I>P. aeruginosa</I> biofilm-related infections. Furthermore, hybrid formulation with nanomaterials such as nanoparticles becomes an effective alternative strategy to minimize the drug toxicity problem and cytotoxicity properties. For this reason, the present study has employed chitosan oligosaccharide for the synthesis of chitosan oligosaccharide-capped gold nanoparticles (COS-AuNPs). The synthesized COS-AuNPs were then characterized by using UV–Visible spectroscopy, Dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), Field emission transmission electron microscopy (FE-TEM), and Energy dispersive X-ray diffraction (EDX). The synthesized COS-AuNPs were applied for inhibiting <I>P. aeruginosa</I> biofilm formation. Results have shown that COS-AuNPs exhibited inhibition to biofilm as well as eradication to pre-existing mature biofilm. Simultaneously, COS-AuNPs were also able to reduce bacterial hemolysis and different virulence factors produced by <I>P. aeruginosa</I>. Overall, the present study concluded that the hybrid nanoformulation such as COS-AuNPs could act as a potential agent to exhibit inhibitory properties against the <I>P. aeruginosa</I> pathogenesis arisen from biofilm formation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> COS-AuNP was synthesized and subjected to characterization by FTIR, EDX, XRD and FE-TEM. </LI> <LI> COS-AuNP inhibited <I>P. aeruginosa</I> biofilm formation and eradicated the mature biofilm. </LI> <LI> COS-AuNP inhibited hemolytic activity, virulence factors production and motilities. </LI> </UL> </P>
Assessment of antibiotic resistance in bacteriophage-insensitive Klebsiella pneumoniae