Other up-to-date treatment modalities of vitiligo = Other up-to-date treatment modalities of vitiligo

다국어 초록 (Multilingual Abstract)

Vitiligo is an acquired depigmenting disorder that occurs in about 1% of the population. The white macules and patches in vitiligo patients are the consequence of melanocyte destruction in the skin and they can be an emotional stress on the vitiligo patients. The immune modulating agents (systemic/topical steroids, topical calcineurin inhibitors) and phototherapy (narrow band UVB and excimer laser) are the mainstay of current modalities for the treatment of vitiligo. Despite the increased knowledge of pathogenesis and the enthusiastic use of above-mentioned treatment modalities, current management for vitiligo cannot ensure the complete cure. To overcome the limitation, diverse attempts have been tried and various results have been reported. Herein, I will talk about the up-to-date treatment modalities of vitiligo through a review of recently published papers. The talk will include the use of cytokines and its analogue (α-MSH analogue, afamelanotide), inhibitors for cell signaling pathways (Janus kinase inhibitor, tofacitinib), antibiotics (tetracycline and its derivative, minocycline), and lasers (CO² fractional laser) in the treatment of vitiligo. Recent clinical trials and the possible mechanism of each modality will be briefly reviewed.