저강도 초음파가 흰쥐 대퇴골 골절치유와 TGF-β1의 발현에 미치는 영향 = The Effects of Low-intensity Ultrasound on TGF-β1 Expression and Healing of Rat Femur Fracture

다국어 초록 (Multilingual Abstract)

Purpose: The purpose of this study was to investigate the effects of low intensity pulsed ultrasound on TGF-β1 expression and healing of rat femur penetrating fractures. Methods: Rats were anesthetized with ketamine and xylazine. Using aseptic technique, we exposed the lateral right femoral diaphysis with removal of the periosteum. We made one hole along its long axis with an electrically-driven 1.8 mm diameter drill bit. Postoperatively, rats were divided into two groups (a control group, n=15; an experimental group, n=15). The experimental group was treated with low intensity pulsed ultrasound (pulse rate: 1:4, 0.5 W/cm2, 10 minutes, 1 time per day) for 3 weeks. The control group was treated with sham ultrasound (with the US unit turned off). Results: The experimental group achieved more callus formation and TGF-β1 expression than the control group at the 7^th, 14^th and 21^st days after low intensity pulsed ultrasound treatment. Conclusion: This study suggests that low intensity pulsed ultrasound facilitates bone fracture repair, possibly via increased TGF-β1 expression.

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