The goal of the MEDEX‐OP trial was to compare the efficacy of a known effective high‐intensity resistance and impact training (HiRIT) with a low‐intensity exercise control (Buff Bones® [BB]), alone or in combination with antiresorptive bone med...
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https://www.riss.kr/link?id=O111739169
2021년
-
0884-0431
1523-4681
SCI;SCIE;SCOPUS
학술저널
1680-1693 [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
The goal of the MEDEX‐OP trial was to compare the efficacy of a known effective high‐intensity resistance and impact training (HiRIT) with a low‐intensity exercise control (Buff Bones® [BB]), alone or in combination with antiresorptive bone med...
The goal of the MEDEX‐OP trial was to compare the efficacy of a known effective high‐intensity resistance and impact training (HiRIT) with a low‐intensity exercise control (Buff Bones® [BB]), alone or in combination with antiresorptive bone medication, on indices of fracture risk (bone mass, body composition, muscle strength, functional performance), compliance, and safety. Primary study outcomes were 8‐month change in lumbar spine (LS) and total hip (TH) bone mineral density (BMD). Healthy postmenopausal women with low bone mass (T‐score ≤ −1.0) on or off stable doses (≥12 months) of antiresorptive medication were recruited. A total of 115 women (aged 63.6 ± 0.7 years; body mass index [BMI] 25.5 kg/m2; femoral neck [FN] T‐score −1.8 ± 0.1) were randomly allocated to 8‐month, twice‐weekly, 40‐minute HiRIT (5 sets of 5 repetitions, >80% to 85% 1 repetition maximum) or BB (low‐intensity, Pilates‐based training), stratified by medication intake, resulting in four groups: HiRIT (n = 42), BB (n = 44), HiRIT‐med (n = 15), BB‐med (n = 14). HiRIT improved LS BMD (1.9 ± 0.3% versus 0.1 ± 0.4%, p < 0.001) and stature (0.2 ± 0.1 cm versus −0.0 ± 0.1 cm, p = 0.004) more than BB. Both programs improved functional performance, but HiRIT effects were larger for leg and back muscle strength and the five times sit‐to‐stand test (p < 0.05). There was a positive relationship between maximum weight lifted and changes in LS BMD and muscle strength in the HiRIT groups. Exploratory analyses suggest antiresorptive medication may enhance exercise efficacy at the proximal femur and lumbar spine. Exercise compliance was good (82.4 ± 1.3%) and both programs were well tolerated (7 adverse events: HiRIT 4; BB 3). HiRIT improved indices of fracture risk significantly more than Buff Bones®. More trials combining bone medication and bone‐targeted exercise are needed. © 2021 American Society for Bone and Mineral Research (ASBMR).
Ed Bd, Masthead, Comm List and TOC
Journal of Bone and Mineral Research: Volume 36, Number 9, September 2021
Issue Information‐Declaration of Helsinki
Fractures After Denosumab Discontinuation: A Retrospective Study of 797 Cases