RISS 검색 - 해외학술지논문 상세보기

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다국어 초록 (Multilingual Abstract)

Nitrate supplementation improves endothelial function, blood pressure, ejection fraction and overall weight. It also may attenuate the hypoxic ventilatory response (HVR) in healthy individuals. Hypoxic ventilatory response is increased in obese humans when compared to healthy individuals. Therefore, we hypothesize that HVR increases in a rat model of obesity and this increase is mitigated by nitrite supplementation. Two experiments were conducted. In the first, 12 Fischer 344 rats were broken into two groups: Rats fed a standard diet with additional nitrite supplementation (Nitrite) and rats fed a standard diet with no additional supplementation. After 2 months of nitrite supplementation, plethysmography was used to measure ventilation at oxygen levels of 21%, 15%, 12%, and 9%. In the second experiment, 21 Fischer 344 rats were divided into 3 groups: rats fed a high fat diet (HFD), rats fed a high fat diet with nitrite supplementation in their drinking water (HFD‐N), and rats fed a standard diet (Control). After 14 months of diet and nitrite supplementation, all three groups underwent identical plethysmographic measurements to the first cohort. In the first group, as expected, nitrite supplementation significantly reduced HVR. In the second group, contrary to data in humans, the obesity rat model presented a decreased HVR when compared to controls. Nitrite did not alter this obesity induced decrease in ventilation. Nitrite did cause a significant increase in VO2 when compared to both groups. Future studies are needed to determine the mechanisms behind the impact of these interventions on HVR.
Support or Funding Information
This project was funded by the College of Liberal Arts and Sciences and the Health and Human Physiology department at the university of Iowa
This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.