The chronic wound due to the extended inflammatory phase and the reduced vascularization has caused serious problems to human health. Currently, nitric oxide (NO) is an endogenous gas molecule that involves in many physiological processes. However, th...
The chronic wound due to the extended inflammatory phase and the reduced vascularization has caused serious problems to human health. Currently, nitric oxide (NO) is an endogenous gas molecule that involves in many physiological processes. However, the clinical application of NO is limited due to their burst and short half-life release from the biomaterials. In this study, copper nanoparticles (a NO-generating catalyst) were incorporated in the gelatin-based hydrogel (GH) for in situ generation of NO in the presence of endogenous S-nitrosothiol. The fabricated hydrogel presented the sustained release of NO for over 3 weeks within the physiological level, which stimulated the in vitro anti-inflammatory and angiogenic properties. Besides, the chorioallantoic membrane and in vivo animal study also confirm the angiogenic activity of GH/Cu hydrogel. Overall, GH/Cu hydrogel presented as a promising material for wound healing treatment.