In this study, well‐defined, 3D arrays of air‐suspended melt electrowritten fibers are made from medical grade poly(ɛ‐caprolactone) (PCL). Low processing temperatures, lower voltages, lower ambient temperature, increased collector distance, and...
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https://www.riss.kr/link?id=O118247410
2021년
-
1616-5187
1616-5195
SCI;SCIE;SCOPUS
학술저널
n/a-n/a [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
In this study, well‐defined, 3D arrays of air‐suspended melt electrowritten fibers are made from medical grade poly(ɛ‐caprolactone) (PCL). Low processing temperatures, lower voltages, lower ambient temperature, increased collector distance, and...
In this study, well‐defined, 3D arrays of air‐suspended melt electrowritten fibers are made from medical grade poly(ɛ‐caprolactone) (PCL). Low processing temperatures, lower voltages, lower ambient temperature, increased collector distance, and high collector speeds all aid to direct‐write suspended fibers that can span gaps of several millimeters between support structures. Such processing parameters are quantitatively determined using a “wedge‐design” melt electrowritten test frame to identify the conditions that increase the suspension probability of long‐distance fibers. All the measured parameters impact the probability that a fiber is suspended over multimillimeter distances. The height of the suspended fibers can be controlled by a concurrently fabricated fiber wall and the 3D suspended PCL fiber arrays investigated with early post‐natal mouse dorsal root ganglion explants. The resulting Schwann cell and neurite outgrowth extends substantial distances by 21 d, following the orientation of the suspended fibers and the supporting walls, often generating circular whorls of high density Schwann cells between the suspended fibers. This research provides a design perspective and the fundamental parametric basis for suspending individual melt electrowritten fibers into a form that facilitates cell culture.
Polycaprolactone is melt electrowritten as suspended fibers and the ideal processing parameters identified using a test frame. Using this information, such fibers are suspended into 3D arrays with the height controlled by interweaving with a simultaneously printed wall. When dorsal root ganglia are positions onto such fiber arrays, neurites extend extensively, and Schwann cells migrate along the fibers.
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