난소절제 흰쥐에서 신령버섯의 β⁃Glucan과 난각 Ca 복합체가 골 대사에 미치는 효과

다국어 초록 (Multilingual Abstract)

This study was designed to evaluate the effect of Agaricus blazei β-glucan and egg shell calcium complex on bone metabolism in ovariectomized (OVX) rats. Forty Sprague-Dewley female rats, 10 weeks of age (248±1.7 g), were divided into 4 groups and fed on the experimental diets for 6 weeks: sham operated control treated with normal diet containing 0.5% calcium (Sham-C), OVX-control treated with normal diet containing 0.5% calcium (OVX-C), OVX-β-glucan group treated with β-glucan diet containing 0.5% calcium (OVX-G), and OVX-β-glucan egg shell calcium complex treated with OVX-β-glucan egg shell calcium complex containing 0.5% calcium (OVX-GE). Bone weight of femur was higher in the OVX-GE group than in the other OVX groups. Bone mineral density of femur was significantly different (p<0.05) among the experimental groups and showed the highest level in the OVX-GE group. Calcium absorption rate and retention were higher in the β-glucan supplement groups than in the other groups (p＜0.05). Alkaline phosphatase activities and osteocalcin levels of serum showed lower in the β-glucan supplement groups than in the OVX-C group. Deoxypyridinoline crosslink values of urine, indicator of bone absorption, showed the lowest in the OVX-GE group. The β-glucan supplemented groups had a lower bone resorption ratio than in the OVX-C group. We concluded that bioavailability of calcium is higher in β-glucan supplement groups compared to those in OVX rats. From the above results, these findings suggest the possibility of using β-glucan egg shell calcium complex as a functional food material related to bone metabolism, even though there is no significant difference between the groups of β-glucan and β-glucan-egg shell calcium complex supplementation.

목차 (Table of Contents)

• Abstract
• 서론
• 재료 및 방법
• 결과 및 고찰
• 요약
• 감사의 글
• 문헌

참고문헌 (Reference)

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