내장 지방조직의 혈관신생 조절에 대한 hesperidin과 quercetin의 영향 = Effect of hesperidin and quercetin on regulating angiogenesis of visceral adipose tissue

다국어 초록 (Multilingual Abstract)

This study investigated whether hesperidin and quercetin more effectively inhibit weight and angiogenesis of visceral white adipose tissue in mice fed a high-fat diet. Male mice fed a high-fat diet were randomly classified into the following groups: a control group (Con), a group treated with hesperidin alone (Hes), a group treated with quercetin alone (Que), and a group treated with a combination of hesperidin and quercetin (Hes+Que), and were reared for 8 weeks. The weight of visceral white adipose tissue, the size of white adipocytes and glucose levels in blood decreased in Hes, Que and Hes+Que groups compared to the Con group, and decreased more in Hes+Que group compared to Hes and Que groups. Hes, Que, and Hes+Que all decreased gene expression of VEGF and FGF-2, which are angiogenic factors, in visceral white adipose tissue, and the Hes+Que group showed further reductions compared to the Hes and Que groups, respectively. In addition, the gene expression of MMP2 and MMP9 decreased in the Hes, Que and Hes+Que groups compared to Con group, with a more significant decreased in the Hes+Que group compared to Hes and Que groups.
Therefore, this study suggests that hesperidin and quercetin reduce visceral obesity by suppressing angiogenesis in visceral white adipose tissue, and this effect is enhanced by the combined treatment of hesperidin and quercetin.