에스트로젠 수용체알파에 의한 Hypoxia Inducible Factor-1의 전사 활성조절 = Activation of Hypoxia Inducible Factor-1 Alpha by Estrogen Receptor Alpha

다국어 초록 (Multilingual Abstract)

Our previous results showed that hypoxia inducible factor-1 (HIF-1) activated estrogen receptor (ER) in the absence of ligand. In this study, we have studied the effect ER overexpression on the activation of HIF-1. ER overexpression induced transcription activation of hypoxia response element driven luciferase and vascular endothelial growth factor. As a negative control, the effect of ER on androgen receptor response element was used. Our result indicate that the two ERα and HIF-1 signaling pathways shares part of the activation pathway.

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