1 이철주, "바이오마커 연구개발 동향 한국생화학분자생물학회"
2 성수현, "당뇨병 및 골다공증 치료제의 효율적인 신약개발을 위한 생체표지자 및 대리 결과 변수의 역할 및 활용" 대한약학회 52 (52): 331-344, 2008
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5 Cazzola, M, "on behalf of the American Thoracic Society/European Respiratory Society Task Force on outcomes of COPD : Outcomes for COPD pharmacological trials: from lung function to biomarkers" 31 : 416-, 2008
6 Lee, J. W, "Validation of assays for the bioanalysis of novel biomarkers:Practical recommendations for clinical investigation of new drug entities" 132 : 119-, 2003
7 Rolan, P, "Use of biomarkers from drug discovery through clinical practice: Report of the ninth European federation of pharmaceutical sciences conference on optimizing drug development" 73 (73): 284-, 2003
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47 Panzner, P, "Marked up-regulation of T lymphocytes and expression of interleukin-9 in bronchial biopsies from patients with chronic bronchitis with obstruction" 124 : 1909-, 2003
48 Santamaria, F, "Lung structure abnormalities, but normal lung function in pediatric bronchiectasis" 130 : 480-, 2006
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59 Biernacki, W. A, "Increased leukotriene B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD" 58 : 294-, 2003
60 Saetta, M, "Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic onstructive pulmonary disease" 165 : 1404-, 2002
61 Lamkhioued, B, "Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation" 159 : 4593-, 1997
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63 Vila, S, "Importance of serum interleukin-6 as a mediator of systemic inflammation in patients with alpha-1 antitrypsin deficiency" 38 : 263-, 2002
64 Culpitt, S. V, "Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease" 167 : 24-, 2003
65 Brody, A. S, "High-resolution computed tomography of the chest in children with cystic fibrosis:support for use as an outcome surrogate" 29 : 731-, 1999
66 Bucchioni, E, "High levels of interleukin-6 in the exhaled breath condensate of patients with COPD" 97 : 1299-, 2003
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69 Lee, J. W, "Fit-for-purpose method development and validation for successful biomarker measurement" 23 (23): 312-, 2006
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71 Turner, S, "Exhaled nitric oxide in the diagnosis and management of asthma" 8 : 70-, 2008
72 Zeidler, M, "Exhaled nitric oxide in the assessment of asthma" 10 : 31-, 2003
73 Montuschi, P, "Exhaled leukotrienes and prostaglandins in asthma" 109 : 615-, 2002
74 Carpagnano, G. E, "Exhaled interleukin-6 and 8-isoprostane in chronic obstructive pulmonary disease: effect of carbocysteine lysine salt monohydrate (SCMC-Lys)" 505 : 169-, 2004
75 Paredi, P, "Exhaled ethane, a marker of lipid peroxidation,is elevated in chronic obstructive pulmonary disease" 162 : 369-, 2000
76 Montuschi, P, "Exhaled carbon monoxide and nitric oxide in COPD" 120 : 496-, 2001
77 Henriksen, A. H, "Exhaled and nasal NO level in allergic rhinitis: relation to sensitization, pollen season and bronchial hyperresponsiveness" 13 : 301-, 1999
78 Montuschi, P, "Exhaled 8-isoprostane an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers" 162 : 1175-, 2000
79 Vestbo, J, "Evaluation of COPD longitudinally to identify predictive surrogate end-points" 31 : 869-, 2008
80 Harrison, A, "Evaluation and management of the acutely dyspneic patient: the role of biomarkers" 23 : 371-, 2005
81 Liu, L, "Enhanced generation of helper T type 1 and 2 chemokines in allergen-induced aasthma" 169 : 1118-, 2004
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83 Strieter, R. M, "Effects of interferon-gamma 1b on biomarker expression in patients with idiopathic pulmonary fibrosis" 170 : 133-, 2004
84 Woosley, R. L, "Drug development and the FDA’s critical path initiative" 81 (81): 129-, 2007
85 Yamabuki, T, "Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas" 67 (67): 2517-, 2007
86 Keatings, V. M, "Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma" 153 : 530-, 1996
87 Baraldi, E, "Cysteinyl leukotrienes and 8-isoprostane in exhaled breath condensate of children with asthma exacerbations" 58 : 505-, 2003
88 Obase, Y, "Correlation between airway hyperresponsiveness and airway inflammation in a young adult population: eosinophil, ECP, and cytokine levels in induced sputum" 86 : 304-, 2001
89 Brody, A. S, "Computed tomography in the evaluation of cystic fibrosis lung disease" 172 : 1246-, 2005
90 Wark, P, "Clinical usefulness of inflammatory markers in asthma" 2 : 11-, 2003
91 Frank, R, "Clinical biomarkers in drug discovery and development" 2 : 566-, 2003
92 Tonnel, A, "Characteristics of the inflammatory response in bronchial lavage fluids from patients with status asthmaticus" 124 : 267-, 2001
93 Pin, I, "Changes in the cellular profile of induced sputum after allergen-induced asthmatic responses" 145 : 1265-, 1992
94 Revision of Committee, "Challenge and Opportunity on the critical path to new medical product"
95 Saetta, M, "Cellular and structural bases of chronic obstructive pulmonary disease" 163 : 1304-, 2001
96 Kucher, N, "Cardiac biomarkers for risk stratification of patients with acute pulmonary embolism" 108 : 2191-, 2003
97 Pilette, C, "CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge" 23 : 876-, 2004
98 Itillie-Leblond, I, "CC chemokines and interleukin-5 in bronchial lavage fluid from patients with status asthmaticus. Potential implication in eosinophil recruitment" 162 : 586-, 2000
99 Pinto-Plata, V. M, "C-reactive protein in patients with COPD, control smokers and non-smokers" 61 : 23-, 2006
100 Kharitonov, S. A, "Biomarkers of some pulmonary diseases in exhaled breath" 7 : 1-, 2002
101 Soehne, M, "Biomarkers in pulmonary embolism" 19 : 558-, 2004
102 Colburn, W. A, "Biomarkers in drug discovery and development: From target identification through drug marketing" 43 : 329-, 2003
103 Zeisberg, M, "Biomarkers for epithelialmesenchymal transitions" 119 : 1429-, 2009
104 Biomarkers Definition Working Group, "Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework" 69 (69): 89-, 2001
105 Wagner, J. A, "Biomarker validation and qualification: Fitness for use"
106 Park, S, "Association of interleukin-5 and eotaxin with acute exacerbation of asthma" 131 : 283-, 2003
107 Gan, W. Q, "Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a metaanalysis" 59 : 574-, 2004
108 Di Franco, A, "Analysis of sputum cell counts during spontaneous moderate exacerbations of asthma in comparison to the stable phase" 20 : 155-, 2003
109 Montuschi, P, "Analysis of exhaled breath condensate for monitoring airway inflammation" 23 : 232-, 2002
110 Grumelli, S, "An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema" 1 : 8-, 2004
111 Corradi, M, "Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease" 167 : 1380-, 2003
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113 Donaldson, G. C, "Airway and systemic inflammation and decline in lung function in patients with COPD" 128 : 1995-, 2005
114 Nel, A. E, "Acute phase response in bronchiectasis and bronchus carcinoma" 47 : 196-, 1985
115 Saetta, M, "Activated Tlymphocytes and macrophages in bronchial mucosa of subjects with chronic bronchitis" 147 : 301-, 1993
116 "ATS/ERS Rcommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide" 171 : 912-, 2005
117 Boot, J, "A critical appraisal of methods used in early clinical development of novel drugs for the treatment of asthma" 20 : 201-, 2007
118 Abdel-Rahman, A, "A comparative study of two angiogenic facters: vascular endothelial growth factor and angiogenin in induced sputum from asthmatic children in acute attack" 129 : 266-, 2006