From rabbit antibody repertoires to rabbit monoclonal antibodies

다국어 초록 (Multilingual Abstract)

In this review, we explain why and how rabbit monoclonal antibodies have become outstanding reagents for laboratory research and increasingly for diagnostic and therapeutic applications. Starting with the unique ontogeny of rabbit B cells that affords highly distinctive antibody repertoires rich in in vivo pruned binders of high diversity, affinity and specificity, we describe the generation of rabbit monoclonal antibodies by hybridoma technology, phage display and alternative methods, along with an account of successful humanization strategies.

참고문헌 (Reference)

1 FDA, "rabbit polyclonal antibodies"

2 FDA, "rabbit monoclonal antibody"

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