Isolation and Identification of Tyrosinase Inhibitors from Loranthus tanakae

다국어 초록 (Multilingual Abstract)

Various bioactive substances are found in Loranthus tanakae, including quercetin 3-rhamnoside (1), kaempferol 3-rhamnoside (2), rhamnetin 3-rhamnoside (3), and rhamnocitrin 3-rhamnoside (4), which inhibit tyrosinase. These compounds are mainly found in the EtOAc fraction of L. tanakae extract and demonstrate higher rates of tyrosinase inhibition than ascorbic acid, which was used as a control. Our results suggest that L. tanakae extracts can be utilized in skin whitening cosmetics.

참고문헌 (Reference)

1 이수광, "저장기간, 배지종류 및 viscin이 멸종위기종 꼬리겨우살이의 기내 종자발아에 미치는 영향" 한국산림과학회 99 (99): 618-624, 2010

2 이수광, "멸종위기식물 종 꼬리겨우살이의 기주선호성과 서식환경 특성" 한국산림과학회 100 (100): 441-448, 2011

3 이수광, "기주목, 온도 및 습도가 멸종위기 종 꼬리겨우살이 종자의 기외발아에 미치는 영향" 한국산림과학회 99 (99): 871-877, 2010

4 Usuki, A., "The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells" 12 : 43-50, 2003

5 Mason, H.S., "The chemistry of melanin: III. Mechanism of the oxidation of dihydroxyphenylalanine by tyrosinase" 172 : 83-99, 1948

6 Sugimoto, K., "Syntheses of arbutin-α-glycosides and a comparison of their inhibitory effects with those of α-arbutin and arbutin on human tyrosinase" 51 : 798-801, 2003

7 Van Gelder, C. W., "Sequence and structural features of plant and fungal tyrosinases" 45 : 1309-1323, 1997

8 Jung S., "Screening of tyrosinase inhibitor from plants" 27 : 891-896, 1995

9 Mayer, A.M., "Polyphenol oxidases in plants-recent progress" 26 : 11-20, 1986

10 Seo, S., "Mushroom Tyrosinase:recent prospects" 51 : 2837-2853, 2003

11 Cabanes J., "Kojic acid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase" 46 : 982-985, 1994

12 김영균, "Isolation of Flavonol Rhamnosides from Loranthus tanakae and Cytotoxic Effect of Them on Human Tumor Cell Lines" 대한약학회 27 (27): 44-47, 2004

13 Xie, L., "Inhibitory effects of some flavonoids on the activity of mushroom tyrosinase" 68 : 487-491, 2003

14 Kojima, S., "Inhibitory effect of sodium 5, 6-benzylidene ascorbate (SBA) on the elevation of melanin biosynthesis induced by ultraviolet-A (UV-A) light in cultured B-16 melanoma cells" 18 : 1076-1080, 1995

15 박철선, "In vitro Anti-Tyrosinase Activity of Viscumneoside III and Homoflavoyadorinin B Isolated from Korean Mistletoe (Viscum album)" 한국자원식물학회 29 (29): 690-698, 2016

16 Nuhu Alam, "Antioxidant Activities and Tyrosinase Inhibitory Effects of Different Extracts from Pleurotus ostreatus Fruiting Bodies" 한국균학회 38 (38): 295-301, 2010