P228 : A clinicoimmunohistopathologic study of anetoderma = P228 : A clinicoimmunohistopathologic study of anetoderma

다국어 초록 (Multilingual Abstract)

Background: Several reports are available about anetoderma; however, the etiology, pathogenesis and clinicohistopathologic classification are not well characterized. Objectives: To investigate the clinicoimmunohistopathologic characteristics of patients with anetoderma and to examine relationship with immunohistochemistry. Methods: A total of 32 patients diagnosed as anetoderma by skin biopsy were retrospectively reviewed. Immunohistochemistry for elastin, fibrillin-1, metalloproteinase (MMP)-2, 7, 9, 12 and Tissue inhibitor of metalloproteinase (TIMP)-1and 2 was performed. Results: A total of 32 patients were analyzed with a mean age of 31.3 years. Disease duration ranged from 3 days to 10 years. Affected areas included the face, trunk, neck, and upper and lower extremities. No patients accompanied autoimmune diseases. Except 3 patients, others had primary anetoderma. 17 patients presented protruding type, and 13 showed indented type. 9 patients had a solitary lesion, and the others had multiple lesions. Elastin, but not fibrillin-1 immunoreactivity disappeared from the mid dermis. MMP-2 and MMP-9 was markedly increased in epidermal keratinocytes and in the inflammatory infiltrates in lesional dermis. Staining for MMP-7, MMP-12 did not differ from control skin. Staining for TIMP-1 and 2 showed variable results between cases. Conclusion: We described the clinicohistopathological correlation of different type of anetoderma and suggested MMP-2 and MMP-9 could degrade elastic fibers in anetoderma.