Background: Human skin phenotypes such as whitening, wrinkle and moisture are regulated by various factors such as genetic, environmental, and endocrine factors. Among these factors, genetic factor is one of the most potent determinants in skin phenot...
Background: Human skin phenotypes such as whitening, wrinkle and moisture are regulated by various factors such as genetic, environmental, and endocrine factors. Among these factors, genetic factor is one of the most potent determinants in skin phenotypes and has polygenic quantitative traits between races Objectives: We investigated the genetic factors influencingskin phenotypes(whitening, wrinkle and moisture) in Korean women Methods: For the genetic study for skin phenotypes in Korean women, we measured whitening, wrinkle and moisture in 300 women aged 30-50 and finally 78 women who show extreme phenotype were selected. Oragene® saliva kit was used to collect highly pure DNA from saliva of volunteers and Ion Proton™ sequencer was used for exome sequencing Results: Using the logistic regression analysis, we found top 10 genes in each skin phenotypes (whitening, wrinkle and moisture) which are statistically significant Conclusion: Our results suggest that multiple genetic variants in exon region could be determinant of an individual’s skin phenotypes such as whitening, wrinkle and moisture in Korean women