Associations between Oxidized LDL to LDL Ratio, HDL and Vascular Calcification in the Feet of Hemodialysis Patients

다국어 초록 (Multilingual Abstract)

Cardiovascular mortality is associated with vascular calcification (VC) in hemodialysis

(HD) patients. The present study was designed to find factors related with medial

artery calcification on the plain radiography of feet by comparing C-reactive protein

(CRP), plasminogen activator inhibitor type 1 (PAI-1) and lipid profile including

oxidized low density lipoprotein (ox-LDL) and to elucidate associations among these

factors in HD patients. Forty-eight HD patients were recruited for this study. VC in

the feet was detected in 18 patients (37.5%) among total patients and 12 patients

(85.7%) among diabetic patients. Diabetes, cardiovascular disease (CVD), pulse

pressure, ox-LDL/LDL were higher and high density lipoprotein (HDL) was lower in

patients with VC than in patients without VC. Negative associations were found between

HDL and CRP, PAI-1. PAI-1 had positive association with ox-LDL/LDL. History

of CVD was the only determinant of vascular calcification on the plain radiography

of feet. Ox-LDL/LDL, HDL, CRP, and PAI-1 were closely related with one another

in HD patients. History of CVD is the most important factor associated with the

presence of VC and low HDL and relatively high oxidized LDL/LDL ratio may affect

VC formation on the plain radiography in the feet of HD patients.

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