Disc Hemorrhages in Patients with both Normal Tension Glaucoma and Branch Retinal Vein Occlusion in Different Eyes

다국어 초록 (Multilingual Abstract)

Purpose: To document the clinical features of disc hemorrhage in patients with branch retinal vein occlusion (BRVO) and normal tension glaucoma (NTG), and to evaluate the relationship between BRVO and NTG with disc hemorrhages.
Methods: From July 2001 to May 2006, sixteen patients with both NTG and BRVO in different eyes were successively collected from outpatient population of Seoul National University Hospital in this observational case series. The frequency and location of disc hemorrhages, history of associated systemic diseases, and the order of the time of diagnosis between NTG and BRVO were studied.
Results: All patients had unilateral BRVO, and their mean age was 63.3±10.6 years. Disc hemorrhages were detected in eight patients (50%) during the mean follow-up of 26.8 months (range, 3-96 months). Six patients (75%) had disc hemorrhages in the non-BRVO eyes and two patients (25%) in BRVO eyes. Five hemorrhages (62.5%) were located at inferior-temporal quadrant of the optic disc. History of systemic hypertension was identified in 12 patients (75.0%). In 11 patients (68.8%), NTG was diagnosed at the same time as BRVO.
Conclusions: A higher frequency of disc hemorrhages was identified in patients with both BRVO and NTG. Therefore, some cases of NTG, especially with disc hemorrhages, may share a common vascular pathophysiology with BRVO.

참고문헌 (Reference)

1 Klein BE, "et al. Prevalence of glaucoma. The Beaver Dam Eye Study. Ophthalmology 1992" 1499-504,

2 Diehl DLC, "et al. Prevalence and significance of disc hemorrhage in a longitudinal study of glaucoma. Arch Ophthalmol 1990" 545-50,

3 Zhao J, "et al. Arteriovenous crossing patterns in branch retinal vein occlusion. The Eye Disease Case-Control Study Group. Ophthalmology 1993" 423-8,

4 "Yamamoto T. Optic disc hemorrhage in low-tension glaucoma. Ohthalmology 1986" 853-7,

5 Soni KG, "Woodhouse DF. Retinal vascular occlusion as a presenting feature of glaucoma simplex. Br J Ophthalmol 1971" 192-5.

6 Klein BE, "The relationship of optic disc cupping to retinal vein occlusion: The beaver dam eye study" 141 : 859-862, 2006

7 "Sonnsjo B. Similarities between disc haemorrhages and thrombosis of the retinal veins. Int Ophthalmol 1992" 235-8,

8 Luntz MH, "Scjenker HI. Retinal vascular accidents in glaucoma and ocular hypertension. Surv Ophthalmol 1980" 163-7,

9 "Risk factors for branch retinal vein occlusion. Am J Ophthalmol 1993" 286-96,

10 Healey PR, "Optic disc hemorrhages in a population with and without signs of glaucoma" 105 : 216-223, 1998

11 Yamamoto T, "Optic disc hemorrhages detected in a large-scale eye screening project" 13 : 356-360, 2004

12 Lindblom B, "Open angle glaucoma and non-central retinal vein occlusion--the chicken or the egg?" 76 : 329-333, 1998

13 Shapiro A, "Merin S. Intraocular pressure in retinal vein occlusion. Br J Ophthalmol 1984" 26-8,

14 "Krakau CE. Arguments for a vascular glaucoma etiology. Acta Ophthalmol" 433-44, 1993

15 Hayreh SS, "Intraocular pressure abnormalities associated with central and hemicentral retinal vein occlusion" 111 : 133-141, 2004

16 Hendrickx KH, "Hoyng PF. Cumulative incidence of patients with disc hemorrhages in glaucoma and the effect of therapy. Ophthalmology 1994" 1165-72,

17 Lee JB, "Hong YJ. The prevalence of glaucoma in Korean adults. J Korean Ophthalmol Soc 1993" 65-9,

18 Alterman M, "Henkind P. Radial peripapillary capillaries of the retina II. Possible role in Bjerrum scotoma. Br J Ophthalmol 1968" 26-31,

19 "Heijl A. Frequent disk photography and computerized perimetry in eyes with optic disk haemorrhage. Acta Ophthalmol 1986" 274-81,

20 Kim SJ, "Four cases of normal-tension glaucoma with disk hemorrhage combined with branch retinal vein occlusion in the contralateral eye" 137 : 357-359, 2004

21 "Douglas GR. Disc hemorrhage in patients with elevated intraocular pressure. Occurrence with and without field changes. Arch Ophthalmol 1979" 284-5,

22 Ishida K, "Disk hemorrhage is a significantly negative prognostic factor in normal-tension glaucoma" 129 : 707-714, 2000

23 Beaumont PE, "Cup-to-disc ratio, intraocular pressure, and primary open-angle glaucoma in retinal venous occlusion" 109 : 282-286, 2002

24 Allingham RR, "Chronic open-angle glaucoma and normal- tension glaucoma. In: Allingham RR, Damji K, Freedman S, et al. eds. Shield's textbook of glaucoma. 5th ed" Philadelphia: Lippincott Williams & Wilkins 2005

25 Duker JS, "Brown GC. Anterior location of the crossing artery in branch retinal vein occlusion. Arch Ophthalmol 1989" 998-1000,

26 Rubinstein K, "10 years follow-up on 143 patients. Br J Ophthalmol 1976" 148-50,