흰쥐 피부의 창상 치유에 관한 광학현며경 및 전자현며경적 관찰 = Microscopic and Electron Microscopic Study in Rat Skin Wound Healing

다국어 초록 (Multilingual Abstract)

The purpose of this study is to investigate the process of the wound healing and the morphologic mechanism of the scar formation We made primary and secondary wounds in the back of Sprague-Dawley rats. The Wounds were harvested at first day, third day, fifth day, seventh day, fourteenth day and twenty eighth day. The specimens were taken form primary and secondary wound sites and processed for light microscopy and electron microscopy. Generally, secondary wounds showed more prominant contraction and longer tome required for complete healing than primary wounds. Light microscopically, inflarrnnatory reaction was more predominant and the granulation tissue was more abundant in the secondary wounds. Ultrastructurally, neutrophils began to appear at the first day after wound in both primary and secondary wounds. Myoftbroblasts appeared at fourteenth day in the cases of the primary and secondary wounds. Collagen bundles were observed on third day and more increased and thick in the secondary wound at second and fourth weeks. From this study, ``secondary wound showed more severe inflamatory reation, wound contraction and collagen deposition than primary wound We believe that primary wound process is necessary to prevent the complication and to minimize the scar tissue for successful wound healing.