白鼠에 있어서 肝葉切除後 再生期肝의 Hippuric Acid 合成 및 Sulfobromophthaleine의 膽管排泄에 關한 硏究 = Hippuric Acid Synthesis and Biliary Excretion of Sulfobromophthaleine in Rats sfter Partial Hepatectomy

다국어 초록 (Multilingual Abstract)

Recovery of detoxifing and excretory functions of residual liver after parital hepatectomy (removed about 70% of total liver) were studied by determining the detoxication of benzoic acid, as measured by the urinary excertion of hippuric acid, and biliary excretion of sulfobromo phthaleine.
In evaluating the detoxication function, the ration of urinary hippurate-C^14 to benzoate-C^14 (H/B ration) was also estimated by thin layer chromatography after administration of sodium benzoate-C^14 as a more significant criterion of the function than the amount of urinary hippurate (Choi and Ryoo: Kyungpook Med. J., 10:145, 1969).
Immediately after the partial hepatectomy, urinary H/B ratio showed about 2/5 of normal rats while the amount of urinary hippurate was decreased only to 2/3 of normal. The reduction of H/B ratio was more signiifcant on 1-2 days post-hepatectomy and gradually recovered through liver regeneration. Biliary excretion of intravenously injected sulfobromophthaleine also revealed more decrease 1-2 days post-hepatectomy than immediate after the poeration, but on 4 days post-hepatectomy the exretory function was almost completely recovered.