인간 면역결핍 바이러스 양성환자의 항문부 첨규 콘딜로마에서 관찰되는 인유두종 바이러스의 아형에 관한 연구

다국어 초록 (Multilingual Abstract)

Purpose: Anal condyloma is an epithelial proliferative lesion caused by human papillomavirus (HPV) infection. The present study analyzed the HPV types detected in HIV (＋) Korean anal condyloma using PCR-based DNA microarray.
Methods: DNA was extracted from the condyloma tissue of 17 patients including 9 HIV (＋) patients (M：F=15：2, mean age 35 years, 22∼59 years). The 1st PCR was performed with a general primer on L1 region, and nested PCR on the products of the 1st PCR. PCR products were hybridized with a DNA chip.
Results: Fourteen patients (9 HIV (＋), 5 HIV (?)) showed positive HPV DNA. Overall, type 6 was the most common (N=11), and type 11 (N=6), type 53 (N=3) in order. Among HIV (＋) patients, type 6 was also the most common (N=7), then type 11 (N=5) and type 53 (N=3). In contrast to the HIV (?) patients, 5 patients (55.6%) proved to have multiple infections in HIV (＋) patients (2 double, 2 triple, 1 quadruple infection). Four of 9 HIV (＋) patients (44.5%) showed co-infection with high-risk HPV.
Conclusion: Multiple infection and co-infection with high-risk types are more prevalent in HIV (＋) condyloma patients compared to HIV (?) patients. HPV types on HIV (＋) male anal condyloma are similar to those detected in the Korean female uterine cervix.

목차 (Table of Contents)

• 서론
• 방법
• 결과
• 고찰
• 결론
• REFERENCES

참고문헌 (Reference)

1 Palefsky JM, "Virologic, immunologic, and clinical parameters in the incidence and progression of anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual men" 17 : 314-319, 1998

2 Jung WW, "Strategies against human papillomavirus infection and cervical cancer" 42 : 255-266, 2004

3 Gissmann L, "Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers" 80 : 560-563, 1983

4 Kim TJ, "Human papillomavirus infection in anal carcinoma, anal condylomata and rectalcarcinoma" 13 : 7-14, 1997

5 Palefsky JM, "High incidence of anal high-grade squamous intra-epithelial lesions among HIV-positive and HIV-negative homosexual and bisexual men" 12 : 495-503, 1998

6 Munoz N, "Epidemiologic classification of human papillomavirus types associated with cervical cancer" 348 : 518-527, 2003

7 Critchlow CW, "Effect of HIV infection on the natural history of anal human papillomavirus infection" 12 : 1177-1184, 1998

8 Brown DR, "Detection of multiple human papillomavirus types in Condylomata acuminata lesions from otherwise healthy and immunosuppressed patients" 37 : 3316-3322, 1999

9 Choi YD, "Detection of HPV genotypes in cervical lesions by the HPV DNA Chip and sequencing" 98 : 369-375, 2005

10 Brown DR, "Analysis of human papillomavirus types in exophytic condylomata acuminata by hybrid capture and Southern blot techniques" 31 : 2667-2673, 1993

11 Anderson CA, "Anal condyloma: a comparison between HIV positive and negative patients" 70 : 1014-1018, 2004