Does age affect oesophagectomy survival: a cohort study

다국어 초록 (Multilingual Abstract)

This study aimed to assess the effect of age on overall survival and disease‐free survival in patients undergoing curative oesophagectomy for cancer. Overall survival, disease‐free survival and 30‐day mortality rates in patients aged 75 years and older were similar to their younger counterparts. On the basis of these results, older patients should not be precluded from consideration of potentially curative oesophagectomy on age alone, providing surgery may be performed at reasonable risk.






Curative oesophagectomy for oesophageal cancer is associated with considerable potential mortality. Surgeons are increasingly treating older patients presenting with oesophageal cancer as the population ages. The question remains as to the survival in an older population group, many of whom are not fit for combined multimodal therapy. This study aimed to assess the effect of age on overall survival and disease‐free survival in patients undergoing curative oesophagectomy for cancer.
Patient data were analysed from a prospectively maintained database. Demographic, surgical and survival outcomes were compared between groups according to age less than 75 years or 75 and older.
Oesophagectomy was performed in 351 patients between 1990 and 2019 (283 patients <75 years, 68 patients ≥75 years). There was a higher rate of neoadjuvant chemotherapy in the younger group (37.7% versus 7.4%; P < 0.001). The 30‐day mortality between younger and older groups was similar (2.5% and 2.9%; P = 0.827). There was no statistical difference in 5‐year survival rates (50.3% versus 38.6%; P = 0.082) or median survival (22.6 versus 19.3 months; P = 0.053) between groups. There was no statistical difference in 5‐year disease‐free survival (45.1% and 35.7%; P = 0.180).
Overall survival, disease‐free survival and 30‐day mortality rates in patients aged 75 years and older were not statistically different to their younger counterparts. On the basis of these results, older patients should not be precluded from consideration of potentially curative oesophagectomy on age alone, providing surgery may be performed at reasonable risk.