Acetyl Saliylic acid의 粒子度에 따른 Bio-availability에 關한 硏究 = A study on the Bio-availability of Acetyl Salicylic acid depending on particle sizes

국문 초록 (Abstract)

해열 진통제의 一種인 Aspirin(Acetyl Salicylic acid)을 粒子度를 달리하여 生物學的 實驗法을 選擇하여 時間當 尿中 藥物排泄量을 측정하였다.
50mesh, 100mesh, 200mesh 粒子度의 Aspirin 一定量을 건강한 成人 男女에게 隔主間으로 投與한 후 尿中의 藥物排泄量을 비교 관찰하였다.
그 결과 尿中의 總 Aspirin 排泄量은 95% 이상이었으며, 藥物 服用後 4時間後에 100mesh, 200mesh 粒子度의 Aspirin은 最大의 排泄量을 나타냈으며, 50mesh 粒子度의 Aspirin은 6時間後에 最大의 排泄量을 나타내었다.
또한 粒子度가 가장 작은 200mesh 粒子度의 Aspirin은 아주 급작한 排泄量 curve를 나타내나 粒子度가 클수록 즉 100mesh, 50mesh 粒子度 順으로 다소 완만한 排泄量 curve를 나타낸다.
이러한 점으로 미루어 볼 때 藥物의 粒子度가 작을수록 吸收, 排泄이 신속하게 일어나며 粒子度가 클수록 吸收, 排泄이 느리게 나타냄을 알 수 있다.
또한 粒子度가 작을수록 藥物作用은 빨리 나타나며 藥物作用 持續時間이 짧고, 粒子度가 클수록 藥物作用은 늦게 나타나며 藥物作用 持續時間이 길다는 것을 알 수 있다.

다국어 초록 (Multilingual Abstract)

In order to examine the rapidity of absorption of drugs into the blood and the operating time of drugs, a dose of Aspirin powders of different sizes, was orally ad-ministered to a healthy man and woman every other week, and the amount of total Aspirins excreted into the urine according to the particle sizes was measured by the hour.
The total amount of Aspirin excreted into the urine showed more than 95% of that administered orally. The measurement of Aspirin excretion indicated that ad-ministration of particle sizes 100 mesh and 200 mesh resulted in the largest amount of Aspirin in the excretion 4 hours after administration, and particle sizes 50 mesh resulted n the largest amount of Aspirin in the excretion 6 hours after administration. In the relation diagram of time and excretion, the case of particle sizes 200 mesh showed an abrupt curve. In the other words, the administration of particle sizes 200 mesh caused the fastest excretion and the largest amount of Aspirin. On the other hand, the administration of particle sizes 100 mesh and 50 mesh showed the relatively smooth curves.
As a result, the measured value indicated that as the particle sizes became smaller, the time required to absorb drugs into the blood and to excrete into the urine lessend gradually, and that as the particle size became larger, the time required increased gradually.