말초신경 손상 후 뇌 기저핵 및 척수에서 α₂-아드레날린성 수용체 아형의 변화 = The Changes of α₂-Adrenergic Receptor Subtypes in Basal Ganglia and Spinal Cord in Peripheral Nerve Injured Rats

다국어 초록 (Multilingual Abstract)

Background: α₂-adrenergic receptor agonists have been in clinical use for decades, primarily in the treatment of hypertension. In recent years, they have found wider application, particularly in the fields of anesthesia and pain management. This study was aimed to investigate the changes of α₂-adrenergic receptor subtypes in the brain and spinal cord after experimental peripheral nerve injury (PNI).
Material and Method: Sprague-Dawley rats weigh 170-240 g sustained a PNI or sham surgery. Tactile threshold was measured as the frequency of foot withdrawals elicited by a defined mechanical stimulus with von Frey filaments at preinjury and 3, 7, and 10 days after PNI. α_(2A), α_(2B), and α_(2C)-adrenoceptors of basal ganglia in brain and lumbar spinal cord were measured by real time RT-PCR at preinjury and 3, 7, and 10 days after PNI.
Results: Tactile thresholds were significantly decreased at 3, 7, and 10 days after PNI. α_(2A), α_(2B), and α_(2C)-adrenergic receptor subtypes were significantly decreased in basal ganglia and increased in lumbar spinal cord after PNI.
Conclusion: PNI by a simple sciatic nerve clamping can be produced a mechanical allodynia. The α_(2A), α_(2B), and α_(2C)-adrenergic receptors after PNI might be regulated by an inverse pattern at supraspinal and spinal levels.

목차 (Table of Contents)

• 목차
• 서론 = 2
• 대상 및 방법 = 4
• 결과 = 9
• 고찰 = 16
• 요약 = 20
• 참고문헌 = 21
• 영문초록 = 25