2000-2001년 서울 북부 지역 홍역 유행의 양상 = Clinical Study of Measles in Northern Seoul District during 2000-2001

다국어 초록 (Multilingual Abstract)

Purpose : To investigate the clinical features of measles outbreak, we studied epidemics of measles during 2000-2001 in northern Seoul district.
Materials and Methods : Among 208 patients under 15 years of age who visitied or admitted to our hospital from April. 2000 to February, 2001, we selected 160 patients whose measles IgM antibody was positive. We investigated the age, clinical manifestation, vaccination history, measles IgG antibody.
Results : Forty five percent of the patients were under 12 monthes of age, 30.6% were 12-48 months of age and the rest of the patients were over 48 months of age. This epidemic started in April, 2000 and the number of patients increased abruptly in November, reached to peak in December, after then decreased. Fever, cough, and rash were observed in all patients but rhinorrhea in 69%, conjunctivitis in 49%, and Koplik spot in 65.6%. Complication was noted in 74% of patients, and the most common complication was pneumonia(54.4%), followed by gastroenteritis(28%) and acute otitis media and bronchitis. 32.2% of patients had a history of more than one-dose vaccination, and two-dose of vaccination in 12% of patients. Positive rate of Measles IgG antibody was 92% in vaccinated group.
Conclusion : Routine vaccination of single measles vaccine and enhancement of revaccination at ages of 4-6 years is necessary to prevent outbreaks when measles are prevalent. More studies are required to investigate the cause of high rate of primary vaccine failure.