Role of adipose tissue in the development of non-alcoholic fatty liver disease = Role of adipose tissue in the development of non-alcoholic fatty liver disease

다국어 초록 (Multilingual Abstract)

Non-alcololic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in the liver of a patient with no history of alcohol abuse or other causes for secondary hepatic steatosis. The prevalence of non-alcholic fatty liver disease (NAFLD) is rapidly increasing, however, the pathogenesis of NAFLD has not been completely elucidated. Visceral adipose tissue has increasingly been recognized as a biologically active organ contributing to the pathogenesis of NAFLD. This paper summarizes findings on the role of visceral adipose tissues in the context of fatty liver and liver fibrosis and their potential mechanisms. A thorough insight into the pathophysiologic mechanisms linking adipose tissue with NAFLD may result in the designing of studies investigating new diagnostic marker of NAFLD and clinical trials targeting the treatment of NAFLD.