Background: Inflammatory bowel disease (IBD) presents with various extraintestinal manifestations, especially skin diseases.
Objectives: We aimed to identify the epidemiology and risk of developing skin manifestations in patients with IBD.
Methods: We...
Background: Inflammatory bowel disease (IBD) presents with various extraintestinal manifestations, especially skin diseases.
Objectives: We aimed to identify the epidemiology and risk of developing skin manifestations in patients with IBD.
Methods: We used Korean National Health Insurance Claims database and selected patients with IBD and age/sex-matched non-IBD subjects using the diagnosis code and prescription records of IBD-specific medications from 2013 to 2017. The prevalence and risk of concurrent skin diseases were estimated.
Results: A total of 64,837 patients with IBD was identified. Among 3 categories of reactive, inflammatory, and autoimmune skin diseases, reactive skin eruptions including pyoderma gangrenosum and erythema nodosum were associated with IBD with highest odds ratios. Inflammatory skin diseases including rosacea, psoriasis, atopic dermatitis, hidradenitis suppurativa, and acne conglobata were significantly associated with IBD. The patients with IBD also had a higher risk of autoimmune skin diseases including vitiligo and alopecia areata than non-IBD subjects.
Conclusion: This population-based study suggests that IBD was related to various skin diseases including reactive, inflammatory, and autoimmune skin diseases. Considering these relationships can allow better management of patients with IBD and comorbid skin diseases.