RISS 검색 - 국내학술지논문 상세보기

다국어 초록 (Multilingual Abstract)

Background Lambert-Eaton myasthenic syndrome (LEMS) is a presynaptic neuromuscular junction disorder that is most frequently associated with small-cell lung cancer (SCLC). The titers of antibodies against voltage-gated calcium channels are frequently increased in LEMS, but only rarely is titer of anti-acetylcholine-receptor-binding antibodies (AChR-abs) increased.
Case Report A 57-year-old male was admitted to our hospital due to dry mouth and eyes and progressive proximal limb weakness of 2 months duration. The results of a repetitive nerve stimulation test disclosed all criteria for the electrophysiological LEMS pattern, and the patient’s AChRabs titer was 0.587 nmol/L. At a follow-up performed 5 years after successful treatment of SCLC and LEMS, his AChR-abs titer had decreased to 0.001 nmol/L.
Conclusions We suggest that this was a case of transient pseudopositivity of AChR-abs in SCLC with LEMS.

참고문헌 (Reference)

1 Oh SJ, "Principles of Clinical Electromyography, Case Studies" Williams & Wilkins 21-22, 1998

2 Tabbaa MA, "Malignant thymoma with dysautonomia and disordered neuromuscular transmission" 43 : 955-957, 1986

3 Oh SJ, "MG and LEMS overlap syndrome: case report with electrophysiological and immunological evidence" 116 : 1167-1171, 2005

4 Harper CM Jr, "Lambert-Eaton syndrome, In Myasthenia Gravis and Related Disorders. 2nd ed" Humana Press 209-225, 2009

5 Newsom-Davis J, "Immunological evidence for the co-existence of the Lambert-Eaton myasthenic syndrome and myasthenia gravis in two patients" 54 : 452-453, 1991

6 Fettel M, "Combined Eaton- Lambert syndrome and myasthenia gravis" 28 : 398-, 1978

7 Kaminski HJ, "Autoantibody testing in neuromuscular disorders, part II: neuromuscular junction, hyperexcitability, and muscle disorders" 2 : 96-105, 2000

8 Katz JS, "Acetylcholine receptor antibodies in the Lambert-Eaton myasthenic syndrome" 50 : 470-475, 1998

9 Taphoorn MJ, "A neuromuscular transmission disorder: combined myasthenia gravis and Lambert Eaton syndrome in one patient" 51 : 880-882, 1988

10 Lee SA, "A case of remitted Lambert-Eaton myasthenic syndrome with small cell lung carcinoma following chemotherapy and radiotherapy." 10 : 401-406, 1992