We investigated the protective effects of 3-bromo-4,5-dihydroxybenzaldehyde (BDB) from Polysiphonia morrowii Harvey against hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced apoptosis in Vero cells. BDB exhibited scavengin...
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https://www.riss.kr/link?id=A106346829
2019
-
SCIE,SCOPUS,KCI등재
학술저널
1193-1203(11쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
We investigated the protective effects of 3-bromo-4,5-dihydroxybenzaldehyde (BDB) from Polysiphonia morrowii Harvey against hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced apoptosis in Vero cells. BDB exhibited scavengin...
We investigated the protective effects of 3-bromo-4,5-dihydroxybenzaldehyde (BDB) from Polysiphonia morrowii Harvey against hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced apoptosis in Vero cells. BDB exhibited scavenging activity for DPPH, hydroxyl, and alkyl radicals. BDB also inhibited H<sub>2</sub>O<sub>2</sub>-induced lipid peroxidation, cell death, and apoptosis in Vero cells by inhibiting the production of ROS. To evaluate the molecular mechanisms of apoptosis inhibition, the expression of Bax/Bcl-xL and NF-κB was assessed by western blot assay. BDB significantly suppressed the cleavage of caspase-9 and PARP and reduced Bax levels in H<sub>2</sub>O<sub>2</sub>-induced Vero cells. Besides, BDB suppressed the phosphorylation of NF-κB and the translocation of p65 in H<sub>2</sub>O<sub>2</sub>-induced cells. Furthermore, we evaluated the effect of BDB on ROS production, cell death, and lipid peroxidation in an H<sub>2</sub>O<sub>2</sub>-stimulated zebrafish embryo model. Taken together, these results indicated that ROS generation and cell death were significantly inhibited by BDB in zebrafish embryos, thereby proving that BDB exerts excellent antioxidant activity in vitro and in vivo.
Flavobacterium jocheonensis sp. nov., Isolated from Marine Green Alga Ulva pertusa