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      KCI등재 SCOPUS SCIE

      재발한 위장관 간질성 종양(GISTs) 환자들의 임상양상 분석

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      https://www.riss.kr/link?id=A60186956

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      다국어 초록 (Multilingual Abstract)

      Purpose: Gastrointestinal stromal tumors (GISTs) are of a mesenchymal origin, and they arise predominantly from the gastrointestinal tract. This study aims to aid the post operative management of GIST patients by analyzing the clinical and immunopatho...

      Purpose: Gastrointestinal stromal tumors (GISTs) are of a mesenchymal origin, and they arise predominantly from the gastrointestinal tract. This study aims to aid the post operative management of GIST patients by analyzing the clinical and immunopathological features of recurrent GISTs.
      Methods: We enrolled 98 GIST patients who had been operated on for their primary tumor from 1987 to 2001 at the Catholic Medical Center. Among them, 28 patients had clinical and radiological features that were proved to be recurrence, and the patients’ survival rates were compared according to the treatment modalities.
      Results: When the maximum length of tumor was shorter and the mitotic index lower, then these patients had higher disease free survival rates and lower recurrence rates. The Ki-67 negative group had lower recurrence rates than their Ki-67 positive counterparts. Recurrence was mostly observed as liver metastasis. The mean length of time to recur was 22.96 months. Fifteen patients received additional treatments such as surgery, chemotherapy and radiation therapy, but there was no significant difference in survival rates when they were compared to the 13 patients who did not receive further treatments.
      Conclusion: Of the patients diagnosed with GIST after surgery, those with worse prognostic factors, i.e. a bigger tumor size and higher mitotic index, require more meticulous surveillance for tumor recurrence, and especially for liver recurrence, which was the most common recurrence site, during the follow up exams. In addition, although there have not been any remarkably effective treatments for the recurrent GIST patients, further researches for new therapy such as STI-571 is mandated.

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      목차 (Table of Contents)

      • 서론
      • 방법
      • 결과
      • 고찰
      • 결론
      • 서론
      • 방법
      • 결과
      • 고찰
      • 결론
      • REFERENCES
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      참고문헌 (Reference)

      1 DeMatteo RP, "Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival" 231 : 51-58, 2000

      2 Mochizuki Y, "Treatment and risk factors for recurrence after curative resection of gastrointestinal stromal tumors of the stomach" 28 : 870-875, 2004

      3 Pierie JP, "The effect of surgery and grade on outcome of gastrointestinal stromal tumors" 136 : 383-389, 2001

      4 Eilber FC, "Surgical resection and intraperitoneal chemotherapy for recurrent abdominal sarcomas" 6 : 645-650, 1999

      5 Rajan DK, "Sarcomas metastatic to the liver: response and survival after cisplatin, doxorubicin, mitomycin-C, ethiodol, and polyvinyl alcohol chemoembolization" 12 : 187-193, 2001

      6 Mudan SS, "Salvage surgery for patients with recurrent gastrointestinal sarcoma: prognostic factors to guide patient selection" 88 : 66-74, 2000

      7 Eilber FC, "Recurrent gastrointestinal stromal sarcomas" 9 : 71-95, 2000

      8 Verweij J, "Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial" 364 : 1127-1134, 2004

      9 Ng EH, "Prognostic implications of patterns of failure for gastrointestinal leiomyosarcomas" 69 : 1334-1341, 1992

      10 Ng EH, "Prognostic factors influencing survival in gastrointestinal leiomyosarcomas. Implications for surgical management and staging" 215 : 68-77, 1992

      1 DeMatteo RP, "Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival" 231 : 51-58, 2000

      2 Mochizuki Y, "Treatment and risk factors for recurrence after curative resection of gastrointestinal stromal tumors of the stomach" 28 : 870-875, 2004

      3 Pierie JP, "The effect of surgery and grade on outcome of gastrointestinal stromal tumors" 136 : 383-389, 2001

      4 Eilber FC, "Surgical resection and intraperitoneal chemotherapy for recurrent abdominal sarcomas" 6 : 645-650, 1999

      5 Rajan DK, "Sarcomas metastatic to the liver: response and survival after cisplatin, doxorubicin, mitomycin-C, ethiodol, and polyvinyl alcohol chemoembolization" 12 : 187-193, 2001

      6 Mudan SS, "Salvage surgery for patients with recurrent gastrointestinal sarcoma: prognostic factors to guide patient selection" 88 : 66-74, 2000

      7 Eilber FC, "Recurrent gastrointestinal stromal sarcomas" 9 : 71-95, 2000

      8 Verweij J, "Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial" 364 : 1127-1134, 2004

      9 Ng EH, "Prognostic implications of patterns of failure for gastrointestinal leiomyosarcomas" 69 : 1334-1341, 1992

      10 Ng EH, "Prognostic factors influencing survival in gastrointestinal leiomyosarcomas. Implications for surgical management and staging" 215 : 68-77, 1992

      11 Langer C, "Prognostic factors influencing surgical management and outcome of gastrointestinal stromal tumors" 90 : 332-339, 2003

      12 Emory TS, "Prognosis of gastrointestinal smooth-muscle(stromal) tumors: dependence on anatomic site" 23 : 82-87, 1999

      13 Panizo-Santos A, "Predicting metastatic risk of gastrointestinal stromal tumors: Role of cell proliferation and cell cycle regulatory proteins" 8 : 133-144, 2000

      14 Scaife CL, "Is there a role for surgery in patients with “unresectable” cKIT+ gastrointestinal stromal tumors treated with imatinib mesylate?" 186 : 665-669, 2003

      15 Rudolph P, "Immunophenotype, proliferation, DNA-ploidy, and biological behavior of gastrointestinal stromal tumors: a multivariate clinicopathologic study" 29 : 791-800, 1998

      16 Rudolph P, "Immunophenotype, proliferation, DNA-ploidy, and biological behavior of gastrointestinal stromal tumors: a multivariate clinicopathologic study" 29 : 791-800, 1998

      17 Suster S, "Gastrointestinal stromal tumors" 13 : 297-313, 1996

      18 van der Zwan SM, "Gastrointestinal stromal tumor: 5 years later" 104 (104): 1781-1788, 2005

      19 Thomas RM, "Gastrointestinal cancer; incidence and prognosis by histologic type, SEER population-based data 1973-1987" 75 : 154-170, 1987

      20 Blay JY, "GIST consensus meeting panelists. Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 20-21 March 2004, under the auspices of ESMO" 16 : 566-578, 2005

      21 Miettinen M, "Evaluation of malignancy and prognosis of gastrointestinal stromal tumor: a review" 33 : 478-483, 2002

      22 Samiian L, "Evaluation of gastrointestinal stromal tumors for recurrence rates and patterns of long-term follow-up" 70 : 187-191, 2004

      23 Demetri GD, "Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors" 347 : 472-480, 2002

      24 Joenssu H, "Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor" 344 : 1052-1056, 2001

      25 Fletcher CD, "Diagnosis of gastrointestinal stromal tumors: A consensus approach" 33 : 459-465, 2002

      26 Dematteo RP, "Clinical management of gastrointestinal stromal tumors: Before and after STI-571" 33 : 466-477, 2002

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-11-12 학술지명변경 한글명 : 대한외과학회지 -> Annals of Surgical Treatment and Research KCI등재
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2013-12-30 학술지명변경 외국어명 : Journal of The Korean Surgical Society -> Annals of Surgical Treatment and Research KCI등재
      2011-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2009-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2006-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2005-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2004-01-01 평가 등재후보학술지 유지 (등재후보1차) KCI등재후보
      2002-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 1.39 0.21 0.97
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.73 0.56 0.328 0.06
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