Poster Session : PS-1550 ; COPD : FEV1 and FVC Are Independent Factors Affecting Peptic Ulceration in Chronic Obstructive Pulmonary Disease = Poster Session : PS-1550 ; COPD : FEV1 and FVC Are Independent Factors Affecting Peptic Ulceration in Chronic Obstructive Pulmonary Disease

다국어 초록 (Multilingual Abstract)

Background: Recent researches suggest that chronic obstructive pulmonary disease (COPD) is associated with an increased risk of peptic ulcer disease, but limited data exist on affecting factors in COPD patient with peptic ulcer disease on gastroduodenoscopy. Methods: We retrospectively reviewed medical records on 237 COPD patients who performed gastroduodenoscopy in 2003-2013. Patients were divided into two groups accordingly: peptic ulcer (gastric and/or duodenal ulcer) group and non-ulcerative disease group. Statistical analyses were performed with the logistic regression model to obtain the factors affecting peptic ulceration in COPD patients, controlling confounding factors. Results: The prevalence of peptic ulcer disease was 99 of 237 COPD patients (41.7%) and a male sex had a positive association with peptic ulcer disease (odds ratio[OR], 2.270, 95% confidence interval[CI], 1.189 to 4.332). There was independent relationships between the presence of peptic ulcer disease and both liters of predicted forced expiratory volume in 1s (FEV1) (OR, 0.407, 95% CI, 0.229 to 0.724) and liters of functional vital capacity (FVC) (OR, 1.029, 95% CI, 1.011 to 1.048). Smoking status and corticosteroids, known risk factors of peptic ulcer disease in general population, did not showed expected affect on peptic ulceration. Conclusions: Our findings provide further evidence that COPD is associated with peptic ulcer disease and there is an increased risk for peptic ulcer associated with COPD severity.