Hemoptysis in Quadriplegia with Atrial Fibrillation Who Was Taking Edoxaban: a Case Report

다국어 초록 (Multilingual Abstract)

The direct-acting oral anticoagulants (DOACs) would be the standard treatment for the prevention of stroke and thromboembolism in nonvalvular atrial fibrillation patients. The adverse effects of greatest concern are bleeding especially major bleeding. We present a case of a patient with a history of nonvalvular atrial fibrillation and pacemaker, who developed severe anemia after massive hemoptysis while taking DOAC; however, he has continued taking DOAC. Through this case, we have summarized the current management of major bleeding associated with anticoagulation and discuss the optimal regimen for restarting of anticoagulation therapy

참고문헌 (Reference)

1 Steffel J, "The 2018 European Heart Rhythm Association Practical Guide on the use of nonvitamin K antagonist oral anticoagulants in patients with atrial fibrillation" 39 : 1330-1393, 2018

2 Zhou Z, "Resuming anticoagulants after anticoagulation-associated intracranial haemorrhage : systematic review and metaanalysis" 8 : e019672-, 2018

3 Tapaskar N, "Restarting warfarin vs direct oral anticoagulants after major gastrointestinal bleeding and associated outcomes in atrial fibrillation: a cohort study" 2020

4 Zhou Y, "Restarting of anticoagulation in patients with atrial fibrillation after major bleeding : a meta-analysis" 45 : 591-601, 2020

5 Alirhayim Z, "Restarting anticoagulation and outcomes after major gastrointestinal bleeding in atrial fibrillation : author reply" 114 : 327-328, 2014

6 Murthy SB, "Restarting anticoagulant therapy after intracranial hemorrhage : a systematic review and meta-analysis" 48 : 1594-1600, 2017

7 Gedikli Ö, "Real-life data of major and minor bleeding events with direct oral anticoagulants in the one-year follow-up period : the NOAC-TURK study" 25 : 196-204, 2021

8 Hawryluk GW, "Management of anticoagulation following central nervous system hemorrhage in patients with high thromboembolic risk" 8 : 1500-1508, 2010

9 de Veer AJ, "Management and outcomes of real-world use of non-vitamin-K oral anticoagulants(NOACs)in patients with atrial fibrillation : experience of a dedicated NOAC clinic" 27 : 605-612, 2019

10 Okumura K, "Low-dose edoxaban in very elderly patients with atrial fibrillation" 383 : 1735-1745, 2020

11 Korompoki E, "Long-term antithrombotic treatment in intracranial hemorrhage survivors with atrial fibrillation" 89 : 687-696, 2017

12 Lip GY, "Implications of the CHA(2)DS(2)-VASc and HAS-BLED Scores for thromboprophylaxis in atrial fibrillation" 124 : 111-114, 2011

13 Friberg L, "Evaluation of risk stratification schemes for ischaemic stroke and bleeding in 182 678 patients with atrial fibrillation : the Swedish Atrial Fibrillation cohort study" 33 : 1500-1510, 2012

14 Le G, "Efficacy and safety of aspirin and rivaroxaban for venous thromboembolism prophylaxis after total hip or knee arthroplasty: A protocol for meta-analysis" 99 : e23055-, 2020

15 Giugliano RP, "Edoxaban versus warfarin in patients with atrial fibrillation" 369 : 2093-2104, 2013

16 Liu Z, "Bed rest versus early ambulation with standard anticoagulation in the management of deep vein thrombosis : a meta-analysis" 10 : e0121388-, 2015

17 Garcia CB, "Acute physical exercise is safe in patients with primary antiphospholipid syndrome with exclusive venous thrombosis and under oral anticoagulation with warfarin" 34 : 1737-1741, 2014

18 Writing Group MembersJanuary CT, "2019AHA/ACC/HRS focused update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation : A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society" 16 : e66-e93, 2019

19 January CT, "2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation : a report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines and the Heart Rhythm Society" 74 : 104-132, 2019

20 January CT, "2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society" 64 : e1-e76, 2014